Systems biology in psychiatric research : from high-throughput data to mathematical modeling / edited by Felix Tretter [and others].

Includes bibliographical references and index.

Front Matter -- Introduction. Part Introduction -- Philosophical Aspects of Neuropsychiatry / Felix Tretter -- Neuropsychiatry : Subject, Concepts, Methods, and Computational Models / Felix Tretter, Peter J Gebicke-Haerter -- Introduction to Systems Biology / Marvin Schulz, Edda Klipp -- Mind over Molecule: Systems Biology for Neuroscience and Psychiatry / Denis Noble -- Basics. Part Introduction -- Neuropsychiatry, Psychopathology, and Nosology : Symptoms, Syndromes, and Endophenotypes / Wolfram Kawohl, Paul Hoff -- System Properties of Populations of Neurons in Cerebral Cortex / Walter J Freeman -- Dopamine and the Electrophysiology of Prefrontal Cortical Networks / Patricio O'Donnell -- Research in Molecular Psychiatry. Part Introduction -- Nicotinic Cholinergic Signaling in the Human Brain : Systems Perspective / Arian Mobascher, Georg Winterer -- Progress in Psychopharmacotherapy though Molecular Imaging / Ingo Vernaleken, Gerhard Gruender, Paul Cumming -- The Marriage of Phenomics and Genetical Genomics: A Systems Approach to Complex Trait Analysis / Laura M Saba, Paula L Hoffman, Lawrence E Hunter, Boris Tabakoff -- Data Mining and Modeling. Part Introduction -- From Communicational to Computational: Systems Modeling Approaches for Psychiatric Research / Eduardo R Mendoza -- Network Dynamics as an Interface between Modeling and Experiment in Systems Biology / James Smith, Marc-Thorsten Hutt -- Some Useful Mathematical Tools to Transform Microarray Data into Interactive Molecular Networks / Franziska Matthaus, V Anne Smith, Peter J Gebicke-Haerter -- Biochemical Networks in Psychiatric Disease / Maria Lindskog, Geir Halnes, Rodrigo F Oliveira, Jeanette Hellgren Kotaleski, Kim T Blackwell -- Local Cortical Dynamics Related to Mental Illnesses / Marco Loh, Edmund T Rolls, Gustavo Deco -- Epilogue / Peter J Gebicke-Haerter -- Index.

This first book to provide a comprehensive overview of the recent progress made in this break-through approach includes expert contributions from a variety of disciplines. Particular focus is placed on high-throughput methods and the analysis of data thus obtained, as well as their use in silico experiments so as to gain an insight into the complex biological processes in neuronal systems. A must-have for everyone working in psychiatric research.

Print version record.