Drug disposition and pharmacokinetics : from principles to applications / Stephen H. Curry and Robin Whelpton

Includes bibliographical references and index

Chemical introduction : sources, classification, and chemical properties of drugs -- Drug administration and distribution -- Drug elimination -- Elementary pharmacokinetics -- More complex and model independent pharmacokinetic models -- Kinetics of metabolism and excretion -- Further consideration of clearance, and physiological modelling -- Drug formulation : bioavailability, bioequivalence and controlled-release preparations -- Factors affecting plasma concentrations -- Pharmacogenetics and pharmacogenomics -- Developmental pharmacology and age-related phenomena -- Effects of disease on drug disposition -- Quantitative pharmacological relationships -- Simultaneous measurement of concentrations and effect, and pharmacokinetic/pharmacodynamic (PK/PD) modelling -- Drug monitoring in therapeutics -- Drug interactions -- Drug metabolism and pharmacokinetics in toxicology