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020 _a9780470987810
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020 _a0470028769
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020 _a9780470987803
_q(electronic bk.)
020 _a0470987804
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020 _a1282350161
020 _a9781282350168
024 7 _a10.1002/9780470987810
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035 _a(OCoLC)ocn232611432
037 _a10.1002/9780470987810
_bWiley InterScience
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245 0 0 _aValidation of cell-based assays in the GLP setting :
_ba practical guide /
_cedited by Uma Prabhakar and Marian Kelley.
260 _aChichester, England ;
_aHoboken, NJ :
_bWiley,
_c©2008.
300 _a1 online resource (pages)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aConsiderations while setting up cell-based assays / Marian Kelley -- Development, optimization and validation of cell based assays 1 / Marielena Mata and Thomas Lohr -- Development, optimization and validation of cell based assays 2 / Manjula Reddy and Uma Prabhakar -- Whole blood ex vivo stimulation assay development, optimization and validation / Manjula Reddy and Uma Prabhakar -- Immunohistochemistry assays in GLP studies / Frank Lynch [and others] -- Flow cytometric cell based assays : an overview of general applications / Cuc Davis [and others] -- T-cell surface markers in human peripheral whole blood using flow cytometry / Manjula Reddy [and others] -- Intracellular cytokine detection by flow cytometry / Julie G. Wilkinson, Carlos A. Aparicio and Wade E. Bolton -- Validating reference samples for comparison in regulated ELISPOT assay / Magdalena Tary-Lehmann, Christina D. Hamm and Paul V. Lehmann -- IFN-[gamma] ELISPOT assay validation / Manjula Reddy [and others] -- IL-5 ELISPOT assay validation / Manjula Reddy [and others] -- Validation of the cylex technology to measure T and B cell activation capacity in clinical trials / Marielena Mata, Thomas Lohr and Jaymala Patel -- Development of validated neutralization bioassays / Manoj Rajadhyaksha [and others] -- Endpoint assays in HIV-1 vaccine trials : functioning in a GLP environment / Patricia D'Souza [and others] -- The future direction of cell-based assays / Uma Prabhakar and Marian Kelley.
520 _aThe use of cell-based assays within pharmaceutical and biotechnology companies is driven in large part by the need to evaluate the plethora of drug targets derived from genomics and proteomics. In addition, the potential of biomarkers to facilitate the development of effective and safe drugs is being recognized as an integral part of all phases of drug development, and cell-based technologies are a critical part of biomarker discovery and development. Despite this critical role, cell-based assays have not been standardized and made compliant with Good Laboratory Practice guidelines. In this.
588 0 _aPrint version record.
650 0 _aPharmaceutical biotechnology
_vLaboratory manuals.
650 0 _aAnimal cell biotechnology
_vLaboratory manuals.
650 0 _aBiological assay
_xValidity
_vLaboratory manuals.
650 0 _aCytochemical bioassay
_xValidity
_vLaboratory manuals.
650 2 _aBiological assay.
655 2 _aLaboratory Manuals.
655 4 _aElectronic books.
700 1 _aPrabhakar, Uma.
700 1 _aKelley, Marian.
710 2 _aWiley InterScience (Online service)
773 0 _tWiley e-books
776 0 8 _iPrint version:
_tValidation of cell-based assays in the GLP setting.
_dChichester, England ; Hoboken, NJ : Wiley, ©2008
_z9780470028766
_z0470028769
_w(DLC) 2007047633
_w(OCoLC)181903646
856 4 0 _uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=http://onlinelibrary.wiley.com/book/10.1002/9780470987810
_zWiley Online Library
907 _a.b16538328
_b2022-10-27
_c2019-11-12
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998 _ae
_b2017-12-12
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