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020 _a9780470689332
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024 7 _a10.1002/9780470689332
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035 _a(OCoLC)ocn613339185
037 _a10.1002/9780470689332
_bWiley InterScience
_nhttp://www3.interscience.wiley.com
039 9 _a201902121206
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100 1 _aColeman, Michael D.
245 1 0 _aHuman drug metabolism :
_ban introduction /
_cMichael D. Coleman.
250 _a2nd ed.
260 _aOxford ;
_aHoboken, NJ :
_bWiley-Blackwell,
_c©2010.
300 _a1 online resource (xiv, 346 pages)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _aFront Matter -- Introduction -- Drug Biotransformational Systems-Origins and Aims -- How Oxidative Systems Metabolize Substrates -- Induction of Cytochrome P450 Systems -- Cytochrome P450 Inhibition -- Conjugation and Transport Processes -- Factors Affecting Drug Metabolism -- Role of Metabolism in Drug Toxicity -- Appendix A: Methods in Drug Metabolism -- Appendix B: Metabolism of Major Illicit Drugs -- Appendix C: Examination Techniques -- Appendix D: Summary of Major CYP Isoforms and their Substrates, Inhibitors and Inducers -- Suggested Further Reading -- Index.
520 3 _a(Publisher-supplied data) Human Drug Metabolism, An Introduction, Second Edition provides an accessible introduction to the subject and will be particularly invaluable to those who already have some understanding of the life sciences. Completely revised and updated throughout, the new edition focuses only on essential chemical detail and includes patient case histories to illustrate the clinical consequences of changes in drug metabolism and its impact on patient welfare. After underlining the relationship between efficacy, toxicity and drug concentration, the book then considers how metabolizing systems operate and how they impact upon drug concentration, both under drug pressure and during inhibition. Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained. The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
588 0 _aPrint version record.
650 0 _aDrugs
_xMetabolism.
650 0 _aDrugs
_xPhysiological effect.
650 1 2 _aPharmaceutical Preparations
_xmetabolism.
650 2 2 _aXenobiotics
_xtoxicity.
655 4 _aElectronic books.
710 2 _aWiley InterScience (Online service)
773 0 _tWiley e-books
776 0 8 _iPrint version:
_aColeman, Michael D.
_tHuman drug metabolism.
_b2nd ed.
_dOxford ; Hoboken, NJ : Wiley-Blackwell, ©2010
_z9780470742174
_z0470742178
_w(OCoLC)495596457
856 4 0 _uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=http://onlinelibrary.wiley.com/book/10.1002/9780470689332
_zWiley Online Library
907 _a.b16539904
_b2022-10-20
_c2019-11-12
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998 _ae
_b2017-12-12
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