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020			_a9783031243455 _9978-3-031-24345-5
024	7		_a10.1007/978-3-031-24345-5 _2doi
050		4	_aRC321-580
072		7	_aPSAN _2bicssc
072		7	_aSCI089000 _2bisacsh
072		7	_aPSAN _2thema
082	0	4	_a612.8 _223
245	1	0	_aTrials for Cerebellar Ataxias : _bFrom Cellular Models to Human Therapies / _cedited by Bing-wen Soong, Mario Manto, Alexis Brice, Stefan M. Pulst.
250			_a1st ed. 2023.
264		1	_aCham : _bSpringer International Publishing : _bImprint: Springer, _c2023.
300			_aXI, 727 p. 1 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aContemporary Clinical Neuroscience, _x2627-5341
505	0		_aPart I: Basic Science of Cerebellum and Ataxias -- Functional anatomy of the cerebellum -- Cerebellar physiology -- Cerebellar biochemistry/pharmacology -- Genetics of dominant ataxias -- Autosomal and X-linked degenerative ataxias: from genetics to promising therapeutics -- Seeking therapies for Spinocerebellar Ataxia: from gene silencing to systems-based approaches -- Ion Channel Genes and Ataxia -- Part II: Biomarkers and tools of trials -- How to Design a Therapeutic Trial in SCAs -- Therapy development for spinocerebellar ataxia: Rating Scales and Biomarkers -- Clinical rating scales for ataxia -- Scale for Ocular motor Disorders in Ataxia (SODA): Procedures and Basic Understanding -- Cerebellar learning in the prism adaptation task -- Blood and CSF biomarkers in autosomal dominant cerebellar ataxias -- Part III: Autosomal Dominant Cerebellar Ataxias -- Riluzole in progressive cerebellar ataxias -- ASOs against ATXN2 in preclinical and phase 1 trials -- Antisense oligonucleotide therapy against SCA3 -- Spinocerebellar ataxia type 7: From mechanistic pathways to therapeutic opportunities -- Experimental neurotransplantation for cerebellar ataxias -- Development of mesenchymal stem cells therapy for the treatment of polyglutamine SCA: from bench to bedside -- Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia -- Cerebellar Transcranial Magnetic Stimulation in Cerebellar Ataxias -- Physical therapy in Cerebellar Ataxia -- Part IV: Autosomal Recessive Cerebellar Ataxias -- Recent advances on therapeutic approaches for Friedreich's Ataxia -- Therapeutic use of interferon gamma in Friedreich ataxia -- Metabolic treatments of cerebellar ataxia -- Clinical Trials in Fragile X-Associated Tremor/Ataxia Syndrome -- Part V: Sporadic Ataxias -- Therapeutic strategies inimmune-mediated cerebellar ataxias -- Coenzyme Q10 in MSA -- State of the Art and History of Therapeutics in Ataxias.
520			_aDespite the critical importance of the cerebellum in brain functions, the scientific community still lacks effective treatments for most cerebellar ataxias. This book provides a link between the pathogenesis and therapies of cerebellar ataxias while also providing a comprehensive assessment of the preclinical and clinical trials dedicated to cerebellar ataxias over the past 20 years of progress. This is the first book fully dedicated to the trials and therapies of these disorders. It is a truly authoritative and comprehensive reference and comes at a time of major advances in genetic tools and neuroimaging assessments. The coverage begins by laying a foundation of the basic science of the cerebellum and ataxias, proceeds to discuss biomarkers and the tools of trials, offers guidelines on conducting trials, and then explores the full range of therapeutics and their trials, including gene therapy and cell transplantation. The authors are top experts on cerebellar research and the contributing authors have all made seminal contributions in the field.
650		0	_aNeurosciences.
650		0	_aNeurology .
650		0	_aPharmaceutical chemistry.
650		0	_aCognitive neuroscience.
650	1	4	_aNeuroscience.
650	2	4	_aNeurology.
650	2	4	_aPharmaceutics.
650	2	4	_aCognitive Neuroscience.
700	1		_aSoong, Bing-wen. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aManto, Mario. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aBrice, Alexis. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
700	1		_aPulst, Stefan M. _eeditor. _4edt _4http://id.loc.gov/vocabulary/relators/edt
710	2		_aSpringerLink (Online service)
773	0		_tSpringer Nature eBook
776	0	8	_iPrinted edition: _z9783031243448
776	0	8	_iPrinted edition: _z9783031243462
776	0	8	_iPrinted edition: _z9783031243479
830		0	_aContemporary Clinical Neuroscience, _x2627-5341
856	4	0	_uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1007/978-3-031-24345-5
907			_a.b17048904 _b2024-11-06 _c2024-10-22
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998			_ae0001 _b2024-10-22 _cm _dz _feng _gsz _y0 _z.b17048904
999			_c671519 _d671519