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008 110203s2015||||enk o ||1 0|eng|d
020 _a9781139012751 (ebook)
020 _z9781107013841 (hardback)
040 _aUkCbUP
_beng
_erda
_cUkCbUP
050 0 0 _aQH438.5
_b.S97 2015
082 0 0 _a576.5
_223
245 0 0 _aSystems genetics :
_blinking genotypes and phenotypes /
_cedited by Florian Markowetz, Cancer Research UK, Cambridge Research Institute, Michael Boutros, German Cancer Research Center, Heidelberg.
264 1 _aCambridge :
_bCambridge University Press,
_c2015.
300 _a1 online resource (xi, 258 pages) :
_bdigital, PDF file(s).
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aCambridge series in systems genetics
500 _aTitle from publisher's bibliographic system (viewed on 05 Oct 2015).
520 _aWhereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
650 0 _aPhenotype.
650 0 _aGenetics.
650 0 _aFunctional genomics.
700 1 _aMarkowetz, Florian,
_eeditor.
700 1 _aBoutros, Michael,
_eeditor.
776 0 8 _iPrint version:
_z9781107013841
830 0 _aCambridge series in systems genetics.
856 4 0 _uhttps://doi.org/10.1017/CBO9781139012751
907 _a.b16845705
_b2020-12-22
_c2020-12-22
942 _n0
998 _a1
_b2020-12-22
_cm
_da
_feng
_genk
_y0
_z.b16845705
999 _c651913
_d651913