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006			m o d
007			cr |n|||||||||
008			190502s2019 nju ob 001 0 eng d
020			_a9781119081661 _qelectronic book
020			_a1119081661 _qelectronic book
020			_a9781119081692 _qelectronic book
020			_a1119081696 _qelectronic book
020			_z1118279247
020			_z9781118279243
035			_a(OCoLC)1099689803 _z(OCoLC)1099883276 _z(OCoLC)1102072649
040			_aYDX _beng _erda _cYDX _dNST _dUKAHL _dOCLCF _dOH1 _dOCLCO _dYDXIT _dOCLCA _dCUS _dOCLCA
049			_aMAIN
050		4	_aQP551 _b.V43 2019
060	1	4	_aQU 460
072		7	_aMED _x075000 _2bisacsh
072		7	_aSCI _x036000 _2bisacsh
082	0	4	_a612.3/98 _223
245	0	0	_aProteomics for biological discovery / _cedited by Timothy D. Veenstra, John R. Yates III.
250			_aSecond edition.
264		1	_aHoboken, NJ : _bWiley-Blackwell, _c2019.
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references and index.
520			_a'An update to the popular guide to proteomics technology applications in biomedical research Building on the strength of the original edition, this book presents the state of the art in the field of proteomics and offers students and scientists new tools and techniques to advance their own research. Written by leading experts in the field, it provides readers with an understanding of new and emerging directions for proteomics research and applications. Proteomics for Biological Discovery begins by discussing the emergence of proteomics technologies and summarizing the potential insights to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are thoroughly covered, from underlying concepts to limitations and future directions. Later chapters provide an overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, applied proteomics, and bioinformatics relevant to proteomics. Chapters cover: Quantitative Proteomics for Differential Protein Expression Profiling; Protein Microarrays; Protein Biomarker Discovery; Biomarker Discovery using Mass Spectrometry Imaging; Protein-Protein Interactions; Mass Spectrometry Of Intact Protein Complexes; Crosslinking Applications in Structural Proteomics; Functional Proteomics; High Resolution Interrogation of Biological Systems via Mass Cytometry; Characterization of Drug-Protein Interactions by Chemoproteomics; Phosphorylation; Large-Scale Phosphoproteomics; and Probing Glycoforms of Individual Proteins Using Antibody-Lectin Sandwich Arrays. Presents a comprehensive and coherent review of the major issues in proteomic technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Features new coverage of mass spectrometry for high throughput proteomic measurements, and novel quantitation strategies such as spectral counting and stable isotope labeling Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Offers new chapters on biomarker discovery, global phosphorylation analysis, proteomic profiling using antibodies, and single cell mass spectrometry Proteomics for Biological Discovery is an excellent advanced resource for graduate students, postdoctoral fellows, and scientists across all the major fields of biomedical science'--Provided by publisher.
588			_aDescription based on online resource; title from digital title page (viewed on July 18, 2019).
650		0	_aProteomics.
650		0	_aBiology.
650	1	2	_aProteomics. _0(DNLM)D040901
650	2	2	_aComputational Biology _xmethods. _0(DNLM)D019295Q000379
650		7	_aMEDICAL / Physiology. _2bisacsh
650		7	_aSCIENCE / Life Sciences / Human Anatomy & Physiology. _2bisacsh
650		7	_aBiology. _2fast _0(OCoLC)fst00832383
650		7	_aProteomics. _2fast _0(OCoLC)fst01079785
655		4	_aElectronic books.
700	1		_aVeenstra, Timothy Daniel, _d1966- _eeditor.
700	1		_aYates, John R., _cIII, _eeditor.
776	0	8	_iPrint version: _z1118279247 _z9781118279243 _w(OCoLC)1049795667
856	4	0	_uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9781119081661 _zWiley Online Library
907			_a.b16817564 _b2022-11-04 _c2020-07-17
942			_n0
998			_ae _b2020-07-17 _cm _dz _feng _gnju _y0 _z.b16817564
999			_c649165 _d649165