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| 001 | on1074297180 | ||
| 005 | 20250919141841.0 | ||
| 006 | m o d | ||
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| 008 | 181119t20192019nju ob 001 0 eng | ||
| 010 | _a 2018055539 | ||
| 020 |
_a9781119274322 _q(electronic book) |
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_a111927432X _q(electronic book) |
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| 020 |
_a9781119274308 _q(electronic book) |
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| 020 |
_a1119274303 _q(electronic book) |
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| 020 |
_a9781119274315 _q(electronic book) |
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| 020 |
_a1119274311 _q(electronic book) |
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| 020 |
_z9781119274292 _q(hardcover) |
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| 029 | 1 |
_aAU@ _b000065218960 |
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| 029 | 1 |
_aCHNEW _b001048771 |
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| 029 | 1 |
_aCHVBK _b565571702 |
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| 035 | _a(OCoLC)1074297180 | ||
| 040 |
_aDLC _beng _erda _epn _cDLC _dOCLCO _dOCLCF _dNST _dYDX _dEBLCP _dDG1 _dYDX _dMERER _dOCLCQ _dBRX _dOCLCQ |
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| 042 | _apcc | ||
| 049 | _aMAIN | ||
| 050 | 1 | 4 |
_aQD79.C454 _bS275 2019 |
| 072 | 7 |
_aSCI _x013010 _2bisacsh |
|
| 082 | 0 | 0 |
_a543/.84 _223 |
| 245 | 0 | 0 |
_aSample preparation in LC-MS bioanalysis / _cedited by Wenkui Li, Wenying Jian, and Yunlin Fu. |
| 246 | 3 | _aSample preparation in liquid chromatography-mass spectrometry bioanalysis | |
| 264 | 1 |
_aHoboken, NJ : _bJohn Wiley & Sons, Inc., _c2019. |
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| 264 | 4 | _c©2019 | |
| 300 | _a1 online resource | ||
| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bn _2rdamedia |
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| 338 |
_aonline resource _bnc _2rdacarrier |
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| 504 | _aIncludes bibliographical references and index. | ||
| 588 | 0 | _aOnline resource; title from digital title page (viewed on April 24, 2019). | |
| 505 | 0 | _aIntro; Title Page; Copyright Page; Contents; List of Contributors; Preface; List of Abbreviations; Part I Current Sample Preparation Techniques in LC-MS Bioanalysis; Chapter 1 Basic Sample Preparation Techniques in LC-MS Bioanalysis: Protein Precipitation, Liquid-Liquid Extraction, and Solid-Phase Extraction; 1.1 Introduction; 1.2 Physicochemical Properties of Drugs and Their Metabolites; 1.2.1 Hydrophilicity vs. Lipophilicity of Analyte(s); 1.2.2 Protolytic Properties of Analyte(s); 1.3 Pre-analytical Variables of Analyte(s) of Interest in Biological Matrix; 1.3.1 Stability | |
| 505 | 8 | _a1.3.2 Nonspecific Binding1.3.3 Protein Binding; 1.3.4 Blood-to-plasma Ratio and Red Blood Cell Partition; 1.4 Most Commonly Used Sample Preparation Methods in LC-MS Bioanalysis; 1.4.1 Protein Precipitation (PPT); 1.4.1.1 Water-miscible Organic Solvents; 1.4.1.2 Acids; 1.4.2 Liquid-Liquid Extraction (LLE); 1.4.2.1 Mechanism of LLE and Extraction Recovery; 1.4.2.2 Solvent in LLE; 1.4.2.3 General Procedures in LLE; 1.4.2.4 Application of LLE in LC-MS Bioanalysis; 1.4.2.5 Other Formats of LLE; 1.4.3 Solid-phase Extraction (SPE); 1.4.3.1 SPE Stationary Phases (Sorbents) | |
| 505 | 8 | _a1.4.3.2 Common SPE Platforms in LC-MS Bioanalysis1.4.3.3 General SPE Workflows; 1.4.3.4 Other Formats of SPE; 1.4.4 Combination of PPT, LLE, and/or SPE in LC-MS Bioanalysis; 1.4.4.1 Combination of PPT and LLE; 1.4.4.2 Combination of PPT and SPE; 1.4.4.3 Combination of LLE and SPE; 1.4.5 Summary; References; Chapter 2 Online Extraction and Column Switching Techniques in LC-MS Bioanalysis; 2.1 Introduction; 2.2 System Configuration; 2.2.1 Single-column System; 2.2.2 Dual-column System; 2.2.3 Staggered Parallel Online Extraction Systems; 2.3 Commonly Used Online Extraction Techniques | |
| 505 | 8 | _a2.3.1 Turbulent/High Flow Chromatography2.3.2 Restricted Access Media; 2.3.3 Monolithic Materials; 2.3.4 Hydrophilic Interaction Liquid Chromatography; 2.3.5 Immunoaffinity Extraction; 2.3.6 Disposable Extraction Cartridges -- Online SPE; 2.3.7 Online Extraction of Dried Blood Spot (DBS) Samples; 2.3.8 SPE-MS; 2.4 Considerations for Utilizing Online Extraction Techniques; 2.4.1 Advantages and Limitations; 2.4.2 Strategies for Online Extraction Method Development; 2.5 Summary; References; Chapter 3 Equilibrium Dialysis, Ultracentrifugation, and Ultrafiltration in LC-MS Bioanalysis | |
| 505 | 8 | _a3.1 Introduction3.2 Challenges and Considerations; 3.3 Experimental Procedures; 3.3.1 Equilibrium Dialysis; 3.3.2 Ultrafiltration; 3.3.3 Ultracentrifugation; 3.4 Summary; References; Chapter 4 Phospholipid Depletion Techniques in LC-MS Bioanalysis; 4.1 Introduction; 4.2 Impact of Phospholipids on Bioanalytical Methods; 4.3 Investigating Matrix Effects Associated with Phospholipids; 4.4 Minimizing Matrix Effects Associated with Phospholipids; 4.4.1 Sample Dilution; 4.4.2 Column Manipulations; 4.4.3 Internal Standards; 4.4.4 Ionization Choice; 4.4.5 Other Experimental Modifications | |
| 650 | 0 | _aLiquid chromatography. | |
| 650 | 0 | _aMass spectrometry. | |
| 650 | 0 | _aBiotechnology. | |
| 650 | 7 |
_aSCIENCE _xChemistry _xAnalytic. _2bisacsh |
|
| 650 | 7 |
_aBiotechnology. _2fast _0(OCoLC)fst00832729 |
|
| 650 | 7 |
_aLiquid chromatography. _2fast _0(OCoLC)fst00999526 |
|
| 650 | 7 |
_aMass spectrometry. _2fast _0(OCoLC)fst01011435 |
|
| 655 | 0 | _aElectronic books. | |
| 655 | 4 | _aElectronic books. | |
| 700 | 1 |
_aLi, Wenkui, _d1964- _eeditor. |
|
| 700 | 1 |
_aJian, Wenying, _eeditor. |
|
| 700 | 1 |
_aFu, Yunlin, _d1980- _eeditor. |
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| 776 | 0 | 8 |
_iPrint version: _tSample preparation in LC-MS bioanalysis. _dHoboken, NJ : Wiley, [2019] _z9781119274292 _w(DLC) 2018046969 |
| 856 | 4 | 0 |
_uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9781119274315 _zWiley Online Library |
| 907 |
_a.b16817485 _b2022-11-07 _c2020-07-17 |
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