| 000 | 05674cam a2200757 i 4500 | ||
|---|---|---|---|
| 001 | ocn973733402 | ||
| 005 | 20250919141839.0 | ||
| 006 | m o d | ||
| 007 | cr ||||||||||| | ||
| 008 | 170222s2017 nju o 001 0 eng | ||
| 010 | _a 2017008527 | ||
| 020 |
_a9781119264453 _q(ePub) |
||
| 020 |
_a1119264456 _q(ePub) |
||
| 020 |
_a9781119264446 _q(Adobe PDF) |
||
| 020 |
_a1119264448 _q(Adobe PDF) |
||
| 020 | _a9781119264408 | ||
| 020 | _a1119264405 | ||
| 020 |
_z9781118145302 _q(cloth) |
||
| 029 | 1 |
_aAU@ _b000059639131 |
|
| 029 | 1 |
_aCHBIS _b011150716 |
|
| 029 | 1 |
_aCHNEW _b000964861 |
|
| 029 | 1 |
_aCHVBK _b495227269 |
|
| 029 | 1 |
_aCHVBK _b508819903 |
|
| 029 | 1 |
_aDEBSZ _b493821198 |
|
| 029 | 1 |
_aGBVCP _b1014965756 |
|
| 029 | 1 |
_aAU@ _b000062393238 |
|
| 035 | _a(OCoLC)973733402 | ||
| 040 |
_aDLC _beng _erda _epn _cDLC _dNST _dDG1 _dIDEBK _dEBLCP _dOCLCO _dOCLCQ _dUAB _dUPM _dOCLCQ _dDEBSZ _dOCLCQ _dCASUM _dOCLCO _dMERER _dOCLCO _dOCLCF _dOCLCQ _dKSU |
||
| 042 | _apcc | ||
| 049 | _aMAIN | ||
| 050 | 0 | 0 | _aQD478 |
| 072 | 7 |
_aMED _x071000 _2bisacsh |
|
| 082 | 0 | 0 |
_a615.1028/4 _223 |
| 100 | 1 |
_aByrn, Stephen R., _eauthor. |
|
| 245 | 1 | 0 |
_aSolid state properties of pharmaceutical materials / _cStephen R. Byrn, George Zografi, Xiaoming (Sean) Chen. |
| 264 | 1 |
_aHoboken, NJ : _bWiley, _c2017. |
|
| 300 | _a1 online resource | ||
| 336 |
_atext _btxt _2rdacontent |
||
| 337 |
_acomputer _bc _2rdamedia |
||
| 338 |
_aonline resource _bcr _2rdacarrier |
||
| 500 | _aIncludes index. | ||
| 588 | 0 | _aPrint version record and CIP data provided by publisher. | |
| 505 | 0 | _aSolid-State Properties of Pharmaceutical Materials; Contents; Preface; Acknowledgments; 1 Solid-State Properties and Pharmaceutical Development; 1.1 Introduction; 1.2 Solid-State Forms; 1.3 ICH Q6A Decision Trees; 1.4'Big Questions' for Drug Development; 1.5 Accelerating Drug Development; 1.6 Solid-State Chemistry in Preformulation and Formulation; 1.7 Learning Before Doing and Quality by Design; 1.8 Performance and Stability in Pharmaceutical Development; 1.9 Moisture Uptake; 1.10 Solid-State Reactions; 1.11 Noninteracting Formulations: Physical Characterizations; References; 2 Polymorphs. | |
| 505 | 8 | _a2.1 Introduction2.2 How Are Polymorphs Formed?; 2.3 Structural Aspect of Polymorphs; 2.3.1 Configurational Polymorphs; 2.3.2 Conformational Polymorphs; 2.4 Physical, Chemical, and Mechanical Properties; 2.4.1 Solubility; 2.4.2 Chemical Stability; 2.4.3 Mechanical Properties; 2.5 Thermodynamic Stability of Polymorphs; 2.5.1 Monotropy and Enantiotropy; 2.5.2 Burger and Rambergers Rules; 2.5.3 vant Hoff Plot; 2.5.4 DG/Temperature Diagram; 2.6 Polymorph Conversion; 2.6.1 Solution-Mediated Transformation; 2.6.2 Solid-State Conversion; 2.7 Control of Polymorphs; 2.8 Polymorph Screening. | |
| 505 | 8 | _a2.9 Polymorph PredictionReferences; 3 Solvates and Hydrates; 3.1 Introduction; 3.2 Pharmaceutical Importance of Hydrates; 3.3 Classification of Pharmaceutical Hydrates; 3.4 Water Activity; 3.5 Stoichiometric Hydrates; 3.6 Nonstoichiometric Hydrates; 3.7 Hydration/Dehydration; 3.8 Preparation and Characterization of Hydrates and Solvates; References; 4 Pharmaceutical Salts; 4.1 Introduction; 4.2 Importance of Pharmaceutical Salts; 4.3 Weak Acid, Weak Base, and Salt; 4.4 pH-Solubility Profiles of Ionizable Compounds; 4.5 Solubility, Dissolution, and Bioavailability of Pharmaceutical Salts. | |
| 505 | 8 | _a4.6 Physical Stability of Pharmaceutical Salts4.7 Strategies for Salt Selection; References; 5 Pharmaceutical Cocrystals; 5.1 Introduction; 5.2 Cocrystals and Crystal Engineering; 5.3 Solubility Phase Diagrams For Cocrystals; 5.4 Preparation of Cocrystals; 5.5 Dissolution and Bioavailability of Cocrystals; 5.6 Comparison of Pharmaceutical Salts and Cocrystals; References; 6 Amorphous Solids; 6.1 Introduction; 6.2 The Formation of Amorphous Solids; 6.3 Methods of Preparing Amorphous Solids; 6.4 The Glass Transition Temperature; 6.5 Structural Features of Amorphous Solids. | |
| 505 | 8 | _a6.6 Molecular Mobility6.6.1 Overview of Molecular Mobility; 6.6.2 Viscosity and Molecular Mobility; 6.6.3 Relaxation Time; 6.6.4 Fragility in Supercooled Liquids; 6.6.5 Diffusive Relaxation Time in the Glassy State; 6.6.6 Secondary Relaxations in Amorphous Solids; 6.7 Mixtures of Amorphous Solids; 6.7.1 Overview; 6.7.2 Thermodynamics of Molecular Mixing in Amorphous Solids; 6.7.3 The Glass Transition Temperature and Molecular Mobility of Miscible Amorphous Mixtures; References; 7 Crystal Mesophases and Nanocrystals; 7.1 Introduction; 7.2 Overview of Crystal Mesophases; 7.3 Liquid Crystals. | |
| 650 | 0 | _aSolid state chemistry. | |
| 650 | 0 |
_aSolid dosage forms _xProperties. |
|
| 650 | 7 |
_aMEDICAL _xPharmacology. _2bisacsh |
|
| 650 | 1 | 2 |
_aPharmaceutical Preparations _xchemistry. _0(DNLM)D004364Q000737 |
| 650 | 2 | 2 |
_aChemistry Techniques, Analytical. _0(DNLM)D002623 |
| 650 | 2 | 2 |
_aDosage Forms. _0(DNLM)D004304 |
| 650 | 2 | 2 |
_aPharmaceutical Preparations _xanalysis. _0(DNLM)D004364Q000032 |
| 650 | 7 |
_aSolid state chemistry. _2fast _0(OCoLC)fst01125442 |
|
| 655 | 4 | _aElectronic books. | |
| 700 | 1 |
_aZografi, George, _eauthor. |
|
| 700 | 1 |
_aChen, Xiaoming _q(Sean), _eauthor. |
|
| 776 | 0 | 8 |
_iPrint version: _aByrn, Stephen R. _tSolid state properties of pharmaceutical materials. _dHoboken, NJ : John Wiley & Sons, 2017 _z9781118145302 _w(DLC) 2017005555 |
| 856 | 4 | 0 |
_uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9781119264408 _zWiley Online Library |
| 907 |
_a.b16816882 _b2022-11-22 _c2020-07-17 |
||
| 942 | _n0 | ||
| 998 |
_a1 _b2020-07-17 _cm _da _feng _gnju _y0 _z.b16816882 |
||
| 999 |
_c649097 _d649097 |
||