000			04955cam a2200613Ii 4500
005			20250930143106.0
006			m o d
007			cr cnu|||unuuu
008			190918t20182018gw ob 001 0 eng d
020			_a9783527699896 _q(electronic bk.)
020			_a3527699899 _q(electronic bk.)
020			_a9783527699902 _q(electronic bk. : oBook)
020			_a3527699902 _q(electronic bk. : oBook)
020			_z9783527340637
020			_z3527340637
035			_a(OCoLC)1004271395 _z(OCoLC)1004364574
035			_a(OCoLC)on1004271395
039		9	_a201911050903 _bmurni _y09-18-2019 _zhafiz _wUKM UBCM Wiley MARC (363 titles).mrc _x333
040			_aNST _beng _erda _epn _cNST _dEBLCP _dNST _dOCLCF _dDG1 _dYDX _dMERER
049			_aMAIN
050		4	_aRS380
072		7	_aMED _x071000 _2bisacsh
082	0	4	_a615.7 _223
245	0	0	_aContinuous biomanufacturing : _binnovative technologies and methods / _cedited by Ganapathy Subramanian.
264		1	_aWeinheim : _bWiley-VCH, _c[2018]
264		4	_cò018
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aContinuous Biomanufacturing: Innovative Technologies and Methods; Contents; List of Contributors; Part One: Overview of State-of-the-Art Technologies and Challenges; Chapter 1: Continuous Bioprocess Development: Methods for Control and Characterization of the Biological System; 1.1 Proposed Advantages of Continuous Bioprocessing; 1.1.1 Introduction; 1.2 Special Challenges for Continuous Bioprocesses; 1.2.1 The Biological System in Continuous Biomanufacturing; 1.2.2 Inherent Changes in the Microbial System -- Problem of Evolution; 1.2.3 Lack of Process Information
505	8		_a1.2.3.1 Models-Based Process Development and Control for Continuous Processes1.2.3.2 Engineering Approach to Complex Systems; 1.2.4 Limited Control Strategies; 1.2.4.1 Traditional Control Strategies for Continuous Cultures; 1.3 Changes Required to Integrate Continuous Processes in Biotech; 1.3.1 A Better Physiological Understanding of the Organisms and Their Responses on the Reactor Environment; 1.3.1.1 Model Complexity; 1.3.1.2 Models; 1.3.2 Model-Based Process Monitoring; 1.3.3 Implementation of Model Predictive Control; 1.3.3.1 Model-Based Control
505	8		_a1.4 Role of Iterative Process Development to Push Continuous Processes in Biotech1.4.1 Methods for Development of Continuous Processes; 1.4.1.1 Alternative: Fed-Batch as a System to Simulate Quasi Steady-State Conditions; 1.4.2 Mimicking Industrial Scale Conditions in the Lab: Continuous-Like Experiments; 1.4.2.1 A Simple Model for Continuous Processes; 1.4.2.2 Continuous-Like Fed-Batch Cultivations; 1.4.3 Fast and Parallel Experimental Approaches with High Information Content; 1.4.3.1 Computer-Aided Operation of Robotic Facilities; 1.4.3.2 Model Building and Experimental Validation
505	8		_a1.5 ConclusionsReferences; Chapter 2: Tools Enabling Continuous and Integrated Upstream and Downstream Processes in the Manufacturing of Biologicals; 2.1 Introduction; 2.2 Continuous Upstream Processes; 2.2.1 Continuous Bioprocesses: With or Without Cell Recycle?; 2.2.2 Early/Scale-Down Perfusion Development; 2.2.3 Feeding and Operational Strategies in Perfusion Processes; 2.2.4 Cell Retention Devices; 2.3 Continuous Downstream Processes; 2.3.1 Continuous Liquid Chromatography (CLC); 2.3.1.1 Continuous Annular Chromatography (CAC)
505	8		_a2.3.1.2 True and Simulated Moving Bed Chromatography (TMB/SMB)2.3.1.3 Multicolumn Countercurrent Solvent Gradient Purification (MCSGP); 2.3.1.4 Periodic Countercurrent Chromatography (PCC); 2.3.1.5 Continuous Countercurrent Tangential Chromatography (CCTC); 2.3.2 Nonchromatographic Continuous Processes; 2.3.2.1 Continuous Aqueous Two-Phase Systems; 2.3.2.2 Continuous Protein Precipitation; 2.3.3 Straight-Through Processes; 2.3.4 Continuous Virus Clearance Processes; 2.4 Integrated Continuous Processes; 2.5 Concluding Remarks; References
588	0		_aOnline resource; title from PDF title page (EBSCO, viewed September 29, 2017).
590			_aJohn Wiley and Sons _bWiley Online Library All Obooks
650		0	_aPharmaceutical biotechnology. _960734
650		0	_aBiopharmaceutics.
650		0	_aBiochemical engineering.
655		4	_aElectronic books.
655		0	_aElectronic books.
700	1		_aSubramanian, G., _d1935- _eeditor.
773	0		_tWiley e-books
776	0	8	_cOriginal _z3527340637 _z9783527340637 _w(OCoLC)967719361
856	4	0	_uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9783527699902 _zWiley Online Library
907			_a.b16758316 _b2022-08-18 _c2019-11-12
942			_n0
914			_avtls003651488
998			_ae _b2019-05-09 _cm _dz _feng _ggw _y0 _z.b16758316
999			_c643718 _d643718