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020 _a9783527694112
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020 _a3527694110
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020 _a9783527694099
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024 7 _a10.1002/9783527694082
_2doi
028 0 1 _aEB00681133
_bRecorded Books
035 _a(OCoLC)954730194
_z(OCoLC)953633623
_z(OCoLC)954193222
_z(OCoLC)960720693
_z(OCoLC)960833896
_z(OCoLC)962902677
_z(OCoLC)964528893
_z(OCoLC)964878533
035 _a(OCoLC)ocn954730194
039 9 _a201911051112
_bmurni
_y09-18-2019
_zhafiz
_wUKM UBCM Wiley MARC (363 titles).mrc
_x139
040 _aDG1
_beng
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049 _aMAIN
050 4 _aRC119
060 4 _aQX 20
072 7 _aHEA
_x039000
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072 7 _aMED
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072 7 _aMED
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072 7 _aMED
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072 7 _aMED
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082 0 4 _a616.9/6
_223
245 0 0 _aComprehensive analysis of parasite biology :
_bfrom metabolism to drug discovery /
_cedited by Sylke Müller, Rachel Cerdan, and Ovidiu Radulescu.
264 1 _aWeinheim, Germany :
_bWiley-VCH,
_c2016.
300 _a1 online resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aDrug discovery in infectious diseases
500 _aIncludes index.
505 0 _aIdentification and Validation of New Drugs and Targets. Discovery of the Mechanism of Action of Novel Compounds That Target Unicellular Eukaryotic Parasites / Daniela Begolo, Christine Clayton -- Antiparasitics from Algae / Stefan Ringgeler, Barbara Kappes -- Contribution of Natural Products to Drug Discovery in Tropical Diseases / Frederick Annang, Olga Genilloud, Francisca Vicente -- Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites / Tina Weber, Paul M Selzer -- Trypanosomal Cysteine Peptidases: Target Validation and Drug Design Strategies / Elany Barbosa Silva, Glaecia Aparecida Nascimento Pereira, Rafaela Salgado Ferreira -- Potential of Pyrimidine Metabolism for Antitrypanosomal Drug Discovery / Maria Valente, Antonio E Vidal, Dolores Gonzalez Pacanowska -- Phosphatidylcholine and Phosphatidylethanolamine Biosynthesis Pathways in Plasmodium / Ewelina Guca, Alicia Contet, Henri J Vial, Kai Wengelnik, Rachel Cerdan -- Immunophilins as Possible Drug Targets in Apicomplexan Parasites / Alessandra Bianchin, Anthony J Chubb, Angus Bell -- Targeting the Atg8 Conjugation Pathway for Novel Anti-Apicomplexan Drug Discovery / Alexia S Miller, Jurgen Bosch -- Turnover of Glycosomes in Trypanosomes : Perspectives for Drug Discovery / Ana Brennand, Eva Rico, Melisa Gualdron-Lopez, Paul AM Michels -- Glideosome of Apicomplexans as a Drug Target / Lauren E Boucher, Jurgen Bosch -- N-Myristoyltransferase as a Target for Drug Discovery in Malaria / James A Brannigan, Anthony J Wilkinson -- Metabolomics in Drug and Target Discovery. Methods to Investigate Metabolic Systems in Trypanosoma / Maria Fatarova, Florian Bellvert, Edern Cahoreau, Frederic Bringaud, Jean-Charles Portais -- The Role of Metabolomics in Antiparasitic Drug Discovery / Carlo R Giannangelo, Katherine M Ellis, Anna E Sexton, Daniel Stoessel, Darren J Creek -- The Importance of Targeting Lipid Metabolism in Parasites for Drug Discovery / Simon A Young, Matthew D Roberts, Terry K Smith -- Carbon Metabolism of Plasmodium falciparum / Marco Biddau, Sylke Muller -- Gene Expression and Its Regulation : A Promising Research Area for Drug Discovery. Epigenetic Gene Regulation: Key to Development and Survival of Malaria Parasites / Sabine Anne-Kristin Fraschka, Richard Bartfai -- Mechanisms Regulating Transcription in Plasmodium falciparum as Targets for Novel Antimalarial Drugs / Evelien M Bunnik, Karine G Le Roch -- Aminoacyl t-RNA Synthetases as Antimalarial Drug Targets / Anmol Chandele, Amit Sharma -- Mathematical Approaches to Drug and Target Discovery. Mathematical Modeling and Omic Data Integration to Understand Dynamic Adaptation of Apicomplexan Parasites and Identify Pharmaceutical Targets / Partho Sen, Henri J Vial, Ovidiu Radulescu -- Understanding Protozoan Parasite Metabolism and Identifying Drug Targets through Constraint-Based Modeling / Francis Isidore Totanes, Sanu Shameer, David R Westhead, Fabien Jourdan, Glenn A McConkey -- Attacking Blood-Borne Parasites with Mathematics / David D Niekerk, Gerald Penkler, Francois Toit, Jacky L Snoep, Barbara M Bakker, Jurgen R Haanstra.
520 _aThis most recent volume in the series on Drug Discovery in Infectious Diseases focusses on the use of metabolic analysis of protozoic parasites for rational drug discovery design. Covering all classes of parasites, this ready reference covers such methodologies as virtual compound, high throughput, and cellular screening, as well as computer-assisted and structure-based drug design, and pathway modelling. Furthermore, several chapters focus on the latest technologies increasingly being used to dissect metabolic pathways and cellular processes, while enzymatic drug targets for which structural, knock out and inhibitor data are available are also included as well as recent antiparasitic agents targeting particular pathways serving as lead compounds for further drug development. With its real-life success stories, this is a must-have for all professionals dealing with drug discovery in parasitology.
588 0 _aOnline resource; title from PDF title page (John Wiley, viewed August 4, 2016).
650 0 _aMedical parasitology.
650 7 _aHEALTH & FITNESS / Diseases / General
_2bisacsh
650 7 _aMEDICAL / Clinical Medicine
_2bisacsh
650 7 _aMEDICAL / Diseases
_2bisacsh
650 7 _aMEDICAL / Evidence-Based Medicine
_2bisacsh
650 7 _aMEDICAL / Internal Medicine
_2bisacsh
650 4 _aMedical.
650 7 _aMedical parasitology.
_2fast
_0(OCoLC)fst01014401
650 2 _aParasitology.
655 4 _aElectronic books.
700 1 _aMüller, Sylke,
_eeditor.
700 1 _aCerdan, Rachel,
_eeditor.
700 1 _aRadulescu, Ovidiu,
_eeditor.
773 0 _tWiley e-books
776 0 8 _iPrint version:
_z3527339043
_z9783527339044
_w(OCoLC)937452336
830 0 _aDrug discovery in infectious diseases.
856 4 0 _uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9783527694082
_zWiley Online Library
907 _a.b16756344
_b2022-11-03
_c2019-11-12
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998 _ae
_b2019-05-09
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