000			03452cam a22006378i 4500
005			20250919132325.0
006			m o d
007			cr |||||||||||
008			190918s2017 nju ob 001 0 eng
010			_a2016-056137
020			_a9781118916926 _q(electronic bk.)
020			_a1118916921 _q(electronic bk.)
020			_z9781118916940
020			_z1118916948
020			_z9781118916933
020			_z111891693X
020			_z9781118916698 _q(cloth)
035			_a(OCoLC)965446691
035			_a(OCoLC)ocn965446691
039		9	_a201911041629 _bros _y09-18-2019 _zhafiz _wUKM UBCM Wiley MARC (363 titles).mrc _x103
040			_aDLC _beng _erda _cDLC _dOCLCO _dOCLCA _dOCLCQ _dDG1 _dSTF _dOCLCO _dNST _dYDX _dOCLCO _dIDEBK _dEBLCP _dOCLCF _dOCLCO _dMERER _dOCLCO _dOTZ
042			_apcc
049			_aMAIN
050	1	0	_aRS403
060	1	0	_aQV 38
072		7	_aMED _x071000 _2bisacsh
082	0	0	_a615.1/9 _223
100	1		_aEl-Kattan, Ayman F., _eauthor.
245	1	0	_aOral bioavailability assessment : _bbasics and strategies for drug discovery and development / _cAyman F. El-Kattan.
263			_a1707
264		1	_aHoboken, NJ : _bJohn Wiley & Sons Inc., _c2017.
300			_a1 online resource
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aDrug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective.
588	0		_aPrint version record and CIP data provided by publisher; resource not viewed.
650		0	_aDental pharmacology.
650		7	_aMEDICAL / Pharmacology _2bisacsh
650		7	_aDental pharmacology. _2fast _0(OCoLC)fst00890550
650		2	_aBiological availability.
650		2	_aDrug Evaluation, Preclinical.
650		2	_aToxicokinetics.
650		2	_aAdministration, Oral.
655		4	_aElectronic books.
773	0		_tWiley e-books
776	0	8	_iPrint version: _aEl-Kattan, Ayman F. _tOral bioavailability assessment. _dHoboken, NJ : John Wiley & Sons Inc., 2017 _z9781118916698 _w(DLC) 2016055388
856	4	0	_uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9781118916926 _zWiley Online Library
907			_a.b16755984 _b2022-11-04 _c2019-11-12
942			_n0
914			_avtls003651255
998			_ae _b2019-05-09 _cm _dz _feng _gnju _y0 _z.b16755984
999			_c643485 _d643485