000			04730cam a2200553Ii 4500
005			20250919130233.0
006			m o d
007			cr cnu|||unuuu
008			181219s2017 gw ob 001 0 eng d
020			_a9783527800599 _q(electronic bk.)
020			_a352780059X _q(electronic bk.)
020			_a9783527800605 _q(electronic bk.)
020			_a3527800603 _q(electronic bk.)
020			_z9783527340750 _q(print)
035			_a(OCoLC)968151085
035			_a(OCoLC)ocn968151085
039		9	_a201904121051 _bemilda _y12-19-2018 _zhafiz
040			_aNST _beng _erda _epn _cNST _dEBLCP _dDG1 _dNST _dIDEBK _dOCLCF _dUPM _dMERUC _dDEBSZ _dXPJ
049			_aMAIN
050		4	_aTA164
072		7	_aSCI _x013060 _2bisacsh
072		7	_aTEC _x009010 _2bisacsh
082	0	4	_a660.6 _223
245	0	0	_aApplied bioengineering : _binnovations and future directions / _cedited by Toshiomi Yoshida.
264		1	_aWeinheim, Germany : _bWiley-VCH, _c2017.
300			_a1 online resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
504			_aIncludes bibliographical references and index.
505	0		_aCover; Title Page; Copyright; Contents; List of Contributors; Chapter 1 Introduction; 1.1 Introduction; 1.2 Enzyme Technology; 1.3 Microbial Process Engineering; 1.3.1 Bioreactor Development; 1.3.2 Measurement and Monitoring; 1.3.3 Modeling and Control; 1.3.4 Solid-State Fermentation; 1.4 Plant Cell Culture; 1.5 Animal Cell Culture; 1.6 Environmental Bioengineering; 1.7 Composition of the Volume; References; Part I Enzyme Technology; Chapter 2 Enzyme Technology: History and Current Trends; 2.1 The Early Period up to 1890; 2.1.1 Observations and Empirical Results; 2.1.2 Theoretical Approaches
505	8		_a2.2 The Period from 1890 to 19402.2.1 Scientific Progress; 2.2.2 Theoretical Developments; 2.2.3 Technological Developments; 2.3 A New Biocatalyst Concept -- Immobilized Enzymes; 2.3.1 Fundamental Research; 2.3.2 Examples of Industrial Development: The Case of Penicillin Amidase (PA) -- Penicillin Hydrolysis and Derivatives; 2.3.3 Examples of Industrial Development: The Case of Sugar Isomerization; 2.4 Expanding Enzyme Application after the 1950s; 2.5 Recombinant Technology -- A New Era in Biocatalysis and Enzyme Technology; 2.5.1 New Enzymes -- A Key to Genetic Engineering
505	8		_a2.5.2 Analytical and Diagnostic Enzymes2.5.3 Expanding Market of Industrial Enzymes; 2.6 Current Strategies for Biocatalyst Search and Tailor Design; 2.6.1 Enzyme Discovery from the Metagenome or Protein Databases; 2.6.2 Protein Engineering of Enzymes; 2.6.3 Enzyme Cascade Reactions; 2.6.4 Metabolic Engineering; 2.7 Summary and Conclusions; Acknowledgment; Abbreviations; References; Chapter 3 Molecular Engineering of Enzymes; 3.1 Introduction; 3.2 Protein Engineering: An Expanding Toolbox; 3.2.1 From Sequence to Fold and Function
505	8		_a3.2.2 Improving Enzyme Properties by Rational Design and Directed Evolution3.2.3 Designing Smart Libraries; 3.2.4 In Vivo Continuous Directed Evolution; 3.2.5 Diversification of Enzyme Functionalities by Recombination; 3.3 High-Throughput Screening Systems; 3.4 Engineered Enzymes for Improved Stability and Asymmetric Catalysis; 3.4.1 Stability; 3.4.1.1 Cellulases; 3.4.1.2 Lipases; 3.4.2 Asymmetric Biocatalysis; 3.5 De Novo Design of Catalysts: Novel Activities within Common Scaffolds; 3.6 Conclusions; References; Chapter 4 Biocatalytic Process Development
505	8		_a4.1 A Structured Approach to Biocatalytic Process Development4.2 Process Metrics; 4.2.1 Reaction Yield; 4.2.2 Productivity; 4.2.3 Biocatalyst Yield; 4.2.4 Product Concentration; 4.3 Technologies for Implementation of Biocatalytic Processes; 4.3.1 Biocatalyst Engineering; 4.3.1.1 Protein and Genetic Engineering; 4.3.1.2 Biocatalyst Immobilization; 4.3.2 Reaction Engineering; 4.3.2.1 Reactant Supply; 4.3.2.2 Product Removal; 4.3.2.3 Two-Phase Systems; 4.4 Industrial Development Examples; 4.4.1 Development of a Biocatalytic Route to Atorvastatin (Developed by Codexis Inc., USA)
588	0		_aOnline resource; title from PDF title page (John Wiley, viewed January 24, 2017).
650		0	_aBioengineering.
650		0	_aSynthetic biology.
655		4	_aElectronic books.
700	1		_aYoshida, T. _q(Toshiomi), _d1939- _eeditor.
773	0		_tWiley e-books
856	4	0	_uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9783527800599 _zWiley Online Library
907			_a.b16668364 _b2022-11-16 _c2019-11-12
942			_n0
914			_avtls003642156
998			_ae _b2018-06-12 _cm _dz _feng _ggw _y0 _z.b16668364
999			_c634972 _d634972