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020 _a9780128005521
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020 _a0128005521
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020 _z9780128005484
020 _a0128005483 (Trade Cloth)
020 _a9780128005484 (Trade Cloth)
024 3 _a9780128005484
029 1 _aGBVCP
_b856733113
035 _a(OCoLC)930023644
_z(OCoLC)932332263
035 _a(OCoLC)ocn930023644
039 9 _y12-21-2016
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049 _aMAIN
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072 7 _aHEA
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072 7 _aMED
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072 7 _aMED
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072 7 _aMED
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082 0 4 _a610.28
_223
245 0 0 _aTranslating regenerative medicine to the clinic /
_cedited by: Jeffrey Laurence ; guest editors: Pedro Baptista Anthony Atala, Mary van Beusekom
264 1 _aLondon :
_bAcademic Press,
_c[2015].
264 4 _cò016
300 _a1 online resource (xiv, 339 pages)
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
500 _aAcademic Press is an imprint of Elsevier
500 _aIncludes index.
505 0 _aFront Cover; Translating Regenerative Medicine to the Clinic; Copyright; Contents; Contributors; I -- Introduction; 1 -- Regenerative Medicine: The Hurdles and Hopes; Key Concepts; 1. INTRODUCTION; 2. ON THE ORIGINS OF REGENERATIVE MEDICINE; 3. FROM CELLS AND SCAFFOLDS TO TISSUES AND ORGANS; 4. BIOMATERIALS, TISSUE AND ORGAN BIOENGINEERING; 5. GENE THERAPY; 6. STEM CELL THERAPIES; 7. FUTURE DIRECTIONS; REFERENCES; II -- Biomaterials and Tissue/Organ Bioengineering; 2 -- Extracellular Matrix as an Inductive Scaffold for Functional Tissue Reconstruction; Key Concepts; 1. INTRODUCTION
505 8 _a2. ECM AS A SCAFFOLD FOR REGENERATIVE MEDICINE2.1 The ECM as a Mechanical Substrate; 2.2 ECM Composition; 2.3 Dynamic Reciprocity; 2.4 Bioactive Degradation Products; 2.5 ECM as an Instructive Niche for Stem Cells; 3. DECELLULARIZATION AND FABRICATION METHODS; 4. TRANSLATIONAL APPLICATIONS OF ECM IN REGENERATIVE MEDICINE; 4.1 Esophageal Disease; 4.2 Volumetric Muscle Loss; 4.3 Temporomandibular Joint Meniscectomy; 5. MECHANISMS OF CONSTRUCTIVE REMODELING; 5.1 Mechanical Forces; 5.2 Modulation of the Host Response; 5.3 ECM Scaffold Degradation
505 8 _a5.4 Undesirable Responses to ECM Scaffold Materials6. CONCLUSIONS; ACKNOWLEDGMENTS; REFERENCES; 3 -- Whole-Organ Bioengineering-Current Tales of Modern Alchemy; Key Concepts; 1. INTRODUCTION; 2. CURRENT STATUS OF ORGAN TRANSPLANTATION; 3. CURRENT STATUS ON ORGAN BIOENGINEERING; 3.1 Liver; 3.2 Intestine; 3.3 Kidney; 3.4 Heart; 3.5 Pancreas; 3.6 Lungs; 4. CURRENT APPLICATIONS FOR BIOENGINEERED ORGANS; 5. CURRENT LIMITATIONS; 5.1 Cell Sources and Expansion; 5.2 Assembly of Patent Vascular Networks; 5.3 Enabling Bioreactor Technologies; 5.4 Regulatory Challenges, Scaling Up, and Other Issues
505 8 _a6. CONCLUSIONSREFERENCES; 4 -- Regenerative Implants for Cardiovascular Tissue Engineering; 1. INTRODUCTION; 1.1 The Path to a Regenerative Approach; 1.2 Brief Historical Overview of Vascular, Heart Valve, and Heart Implants; 1.2.1 Vascular Implants; 1.2.2 Heart Valve; 1.2.3 Whole Heart; 2. TYPES OF REGENERATIVE IMPLANTS-THE CONTINUITY BRIDGE; 2.1 Synthetic; 2.1.1 Degradable Synthetic Polymers; 2.1.2 Fabrication Methods; 2.2 Biologic; 2.2.1 ECM Gels; 2.2.2 Decellularized Scaffolds; 2.2.3 Hybrid; 3. FUNCTION OF IMPLANTS; 3.1 Implants as a Cell Delivery Vehicle Grown In Vitro
505 8 _a3.1.1 Endothelial Progenitor Cells and MSCs3.1.2 Embryonic and Inducible Stem Cells; 3.1.3 BM Cells; 3.1.4 Cell Seeding Techniques; 3.2 Implants as an In Situ'Cell-Free' Tissue Forming Device; 3.3 Implants as a Drug Delivery Vehicle; 4. CLINICAL APPLICATIONS IN CARDIOVASCULAR REPAIR; 4.1 Vascular; 4.1.1 Vascular Patch; 4.1.2 Vascular Grafts; 4.2 Heart Valve; 4.3 Heart; 5. CONCLUSION; ACKNOWLEDGMENT; REFERENCES; 5 -- Tissue Engineering and Regenerative Medicine: Gastrointestinal Application; Key Concepts; 1. THE GASTROINTESTINAL TRACT: OVERVIEW; 2. NEURODEGENERATIVE DISEASES OF THE GI TRACT
520 8 _aThis review of current methodological tools and experimental approaches used by leading translational researchers, discusses the uses of regenerative medicine for different disease treatment areas, including cardiovascular disease, muscle regeneration and regeneration of the bone and skin. Pedagogically, it concentrates on the latest knowledge, laboratory techniques and experimental approaches used by research leaders in the field. It promotes cross-disciplinary communication between the sub-specialties of medicine, but remains unified in theme by emphasising recent innovations, critical barriers to progress, the new tools that are being used to overcome them and specific areas of research that require additional study to advance the field as a whole.
588 0 _aOnline resource; title from title details screen (ScienceDirect, viewed December 2, 2015).
590 _aElsevier
_bScienceDirect All Books
650 0 _aRegenerative Medicine.
650 0 _aClinical medicine.
650 7 _aHEALTH & FITNESS / Holism
_2bisacsh
650 7 _aHEALTH & FITNESS / Reference
_2bisacsh
650 7 _aMEDICAL / Alternative Medicine
_2bisacsh
650 7 _aMEDICAL / Atlases
_2bisacsh
650 7 _aMEDICAL / Essays
_2bisacsh
650 7 _aMEDICAL / Family & General Practice
_2bisacsh
650 7 _aMEDICAL / Holistic Medicine
_2bisacsh
650 7 _aMEDICAL / Osteopathy
_2bisacsh
650 7 _aClinical medicine.
_2fast
_0(OCoLC)fst00864361
650 7 _aRegenerative medicine.
_2fast
_0(OCoLC)fst01745494
655 4 _aElectronic books.
655 0 _aElectronic books.
700 1 _aLaurence, Jeffrey,
_eeditor.
700 1 _aBaptista, Pedro,
_eeditor
700 1 _aAtala, Anthony,
_d1958-
_eeditor.
700 1 _aBeusekom, Mary van,
_eeditor
776 0 8 _iPrint version:
_aLaurence, Jeffrey
_tTranslating Regenerative Medicine to the Clinic
_dSaint Louis : Elsevier Science,c2015
_z9780128005484
856 4 0 _uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=http://www.sciencedirect.com/science/book/9780128005484
907 _a.b16401657
_b2022-11-02
_c2019-11-12
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998 _ae
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