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020 _a9780127999203
_qelectronic bk.
020 _a0127999205
_qelectronic bk.
020 _z9780124201941
020 _z0124201946
029 1 _aAU@
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029 1 _aNZ1
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029 1 _aDEBSZ
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029 1 _aDEBBG
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035 _a(OCoLC)918892654
_z(OCoLC)918932218
_z(OCoLC)918994293
_z(OCoLC)923544167
_z(OCoLC)929142275
035 _a(OCoLC)ocn918892654
039 9 _y12-21-2016
_zhafiz
_wmetacoll.MYUKM.updates.D20160920.T210208.sdallbooks.1 (perolehan)hafizupload21122016.mrc
_x205
040 _aNST
_beng
_erda
_epn
_cNST
_dOPELS
_dYDXCP
_dNST
_dOCLCF
_dEBLCP
049 _aMAIN
050 4 _aQP624.5.M46
072 7 _aSCI
_x007000
_2bisacsh
082 0 4 _a572.8/645
_223
100 1 _aNeidhart, Michel,
_eauthor.
245 1 0 _aDNA methylation and complex human disease /
_cMichel Neidhart.
264 1 _aAmsterdam :
_bElsevier ,
_c2016.
300 _a1 online resource
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
504 _aIncludes bibliographical references and index.
505 0 _a''Front Cover'';''DNA Methylation and Complex Human Disease'';''Copyright Page'';''Contents'';''Preface'';''About the Author'';''1 DNA Methylation {u3848}? Introduction'';''1.1 Epigenetics'';''1.2 Histone Modifications'';''1.2.1 Histone Acetylation and Deacetylation'';''1.2.2 Histone Methylation'';''1.3 DNA Methylation'';''1.3.1 DNA Methyltransferases'';''1.4 Methyl-Binding Domain Proteins'';''1.5 DNA Demethylation'';''1.6 DNA Hydroxymethylation'';''1.7 Differentially Methylated Regions'';''1.8 Nutriepigenomics'';''References''
505 8 _a''2 DNA Methylation and Epigenetic Biomarkers in Cancer''''2.1 Introduction'';''2.1.1 Diagnosis Biomarkers'';''2.1.2 Progression Biomarkers'';''2.1.3 Predictive Biomarkers'';''2.1.4 Discovery of Novel Biomarkers'';''2.2 Cancerogenesis'';''2.3 Epimutations in Cancer'';''2.3.1 Esophageal Adenocarcinoma'';''2.3.2 Gastric Cancer'';''2.3.3 Colorectal Carcinoma'';''2.3.4 Lynch Syndrome'';''2.3.5 Endometrial and Ovarian Cancers'';''2.3.6 Lung Cancer'';''2.3.7 Glioblastoma'';''2.3.8 Hematopoietic Cancers'';''2.4 Conclusion'';''References''
505 8 _a''3 DNA Methylation and Epigenetic Biomarkers in Non-Neoplastic Diseases''''3.1 Introduction'';''3.2 Autoimmunity'';''3.2.1 Type 1 Diabetes'';''3.2.2 Rheumatoid Arthritis'';''3.2.3 Systemic Lupus Erythematosis'';''3.2.4 Inflammatory Bowel Disease, Crohn{u3848}?s Disease, and Ulcerative Colitis'';''3.3 Metabolic Diseases'';''3.3.1 Type 2 Diabetes'';''3.3.2 Heart Failure'';''3.4 Developmental Diseases'';''3.4.1 Imprinting Disorders'';''3.4.2 Arrhythmia'';''3.5 Psychiatric Diseases'';''3.5.1 Major Depressive Disorder'';''3.5.2 Schizophrenia'';''3.6 Conclusion'';''References''
505 8 _a''4 DNA Methylation and Environmental Factors''''4.1 Introduction'';''4.2 Impact of the Environment in Early Life'';''4.2.1 Genomic Imprinting'';''4.2.2 Beckwith-Wiedemann Syndrome'';''4.2.3 Assisted Reproductive Technologies'';''4.2.4 Large Offspring Syndrome'';''4.3 Nutritional Factors'';''4.3.1 Gestational Maternal Nutritional Factors'';''4.3.2 Nutritional Deficiencies'';''4.4 Adverse Environmental Factors'';''4.4.1 Environmental Toxicants'';''4.4.2 Ethanol Consumption'';''4.4.3 Smoking'';''4.5 Immune Activation'';''4.5.1 Asthma and Allergy'';''4.5.2 Bacterial Infections''
505 8 _a''4.5.3 Viral Infections''''4.6 Maternal Mood and Experience in Early Life'';''4.7 Physical Exercise'';''4.8 Conclusion'';''References'';''5 DNA Methylation and Epidemiology'';''5.1 Introduction'';''5.2 Endocrine Disrupting Chemicals'';''5.2.1 Bisphenol-A'';''5.2.2 Diethylstillbestrol'';''5.2.3 Cadmium'';''5.3 Epigenomics and Breast Cancer'';''5.3.1 RASSF1A'';''5.3.2 P16/CDKN2A'';''5.4 Tobacco Smoking'';''5.4.1 F2RL3, Smoking, and Cardiovascular Diseases'';''5.4.2 RUNX3, Smoking, Low Birth Weight, and Lung Carcinomas'';''5.4.3 AHRR, Smoking, and Lung Metastasis''
520 _aDNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylati.
588 0 _aOnline resource; title from PDF title page (EBSCO, viewed August 20, 2015)
590 _aElsevier
_bScienceDirect All Books
650 0 _aDNA
_xMethylation.
650 0 _aMedical genetics.
650 7 _aSCIENCE / Life Sciences / Biochemistry
_2bisacsh
650 7 _aDNA
_xMethylation.
_2fast
_0(OCoLC)fst00886570
650 7 _aMedical genetics.
_2fast
_0(OCoLC)fst01014133
650 4 _aDNA -- Methylation.
650 4 _aEpigenesis, Genetic.
650 4 _aMedical genetics.
655 4 _aElectronic books.
655 0 _aElectronic books.
776 0 8 _cOriginal
_z9780124201941
_z0124201946
_w(OCoLC)885228983
856 4 0 _uhttps://eresourcesptsl.ukm.remotexs.co/user/login?url=http://www.sciencedirect.com/science/book/9780124201941
907 _a.b16401232
_b2022-11-02
_c2019-11-12
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998 _ae
_b2016-08-12
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