000			09998cam a22005057i 4500
005			20250919011909.0
008			160516t20162016enka b 001 0 eng
020			_a9781782621898 _qhardback _cRM388.46
020			_a178262189X _qhardback
039		9	_a201611081135 _bhayat _c201610191549 _dasrul _c201610131409 _dbaiti _c201609281037 _drahah _y05-16-2016 _zrahah
040			_aAU@ _beng _cAU@ _erda _dOCLCO _dYDXCP _dCOD _dBTCTA _dBDX _dCDX _dEQO _dOCLCQ _dLTSCA _dDLC _dUKM _erda
090			_aTD196.D78P428
090			_aTD196.D78 _bP428
245	0	0	_aPharmaceuticals in the environment / _ceditors : R. E. Hester and R. M. Harrison.
264		1	_aCambridge : _bRoyal Society of Chemistry, _c[2016].
264		4	_c©2016.
300			_axviii, 294 pages : _billustrations ; _c25 cm.
336			_atext _2rdacontent
337			_aunmediated _2rdamedia
338			_avolume _2rdacarrier
490	1		_aIssues in environmental science and technology, _x1350-7583 ; _v41
504			_aIncludes bibliographical references and index.
505	2	0	_tThe Pharmaceutical Industry and the Future of Drug Development -- _tDistribution of Pharmaceutical Residues in the Environment -- _tPharmaceuticals in the Marine Environment -- _tSources of Residues in the Environment and their Control -- _tPersistence of Pharmaceutical Residues both in Sewage Treatment Works and the Receiving Environment -- _tEcotoxicology, Environmental Risk Assessment and Potential Impact on Human Health -- _tImpacts of Pharmaceuticals on Terrestrial Wildlife -- _tVeterinary Pharmaceuticals.
505	0		_aMachine generated contents note: The Pharmaceutical Industry and the Future of Drug Development / David Taylor -- 1. Introduction -- 1.1. Historical Background -- 1.2. What is a Pharmaceutical? -- 1.3. Environmental Impact -- 2. The Pharmaceutical Industries -- 3. Research, Discovery and Development -- 3.1. Pre-clinical Trials -- 3.2. Clinical Trials -- 3.3. Environmental Issues -- 4.Commercial Realities -- 4.1. Problems with Patents -- 4.2. Maintaining a Viable Business -- 4.3. Access to Medicines -- 5. The Pharmaceutical Industry in the Future -- 5.1.Commercial Pressures -- 5.2. Environmental Challenges -- 6. Conclusions -- References -- Distribution of Pharmaceutical Residues in the Environment / Vince D'Aco -- 1. Introduction -- 2. Occurrence of Pharmaceuticals -- 3. Reviews of Pharmaceutical Products -- 4. Measured Concentrations -- 5. Modelling to Complement and Extend the Utility of Field Programs -- 5.1. Measure or Model? -- 5.2. Estimates of API Consumption for Use in Modelling Analysis.
505	0		_aNote continued: 5.3. Modelling for Design of Field Surveys -- 5.4. Elucidating Fate and Transport Mechanisms -- 5.5. Critical Evaluation of Measured Concentrations -- 5.6. Modelling to Support Human Health and Environmental Risk Assessments -- 5.7. Models to Evaluate Potential Impacts of Natural and Synthetic Estrogens -- 5.8. Using Models to Evaluate Mitigation Strategies -- 6. Conclusion -- References -- Pharmaceuticals in the Marine Environment / Thomas H. Hutchinson -- 1. Introduction -- 2. Key Sources of Pharmaceuticals Entering the Marine Environment -- 2.1. Human Pharmaceuticals and Illicit Drugs -- 2.2. Veterinary Medicines -- 2.3. Environmental Fate of PhACs in Marine Environments -- 2.4. Concentrations of PhACs Measured in the Marine Environment -- 2.5. Impacts on Marine Organisms -- 2.6. Human Health Concerns -- 3. Conclusions -- References -- Sources of Pharmaceutical Residues in the Environment and their Control / Daniel J. Caldwell -- 1. Introduction and Overview.
505	0		_aNote continued: 2. Pathways of Exposure -- 3. Patient Consumption and Excretion -- 3.1. Human Excretion -- 3.2. APIs Excreted into the Sewage System Undergo Wastewater Treatment -- 4. Emissions from Pharmaceutical Manufacturing -- 5. Unused Medicines and their Disposal -- 5.1. Disposal in Municipal Solid Waste -- 6. Wastewater Treatment -- 7. Hospitals -- 8. Minor Pathways -- 8.1. Exposure through the Consumption of Foods -- 8.2. Exposure through Water Consumption -- 9. Conclusions -- References -- Pharmaceutical Residues in Sewage Treatment Works and their Fate in the Receiving Environment / Paola Verlicchi -- 1. Introduction -- 2. Pharmaceuticals in Municipal Wastewaters -- 2.1. Occurrence in Municipal Sewage -- 2.2. The Fate and Behaviour of Pharmaceuticals in Sewage Works -- 2.3. Removal of Pharmaceuticals during Conventional Wastewater Treatment -- 2.4. Occurrence in Sewage Sludge -- 3. Need for Advanced Treatment and Sustainability Implications.
505	0		_aNote continued: 4. Pharmaceuticals in Receiving Waters -- 4.1. Occurrence -- 4.2. Fate and Behaviour -- 5. Significance of Levels of Pharmaceuticals in Waters -- 6. Discussion -- 6.1. Recommendations to Reduce Pharmaceutical Inputs -- 7. Summary -- References -- Ecotoxicology, Environmental Risk Assessment and Potential Impact on Human Health / Reinhard Lange -- 1. Introduction -- 2. Some Relevant Pharmacology -- 2.1. Pharmacokinetics -- 2.2. Pharmacodynamics -- 3. General Approaches and Data Availability -- 3.1. Dealing with Data Distributions -- 3.2. What is a'Safe' Concentration? -- 3.3. Data Feast and Famine -- 4. Potential Risks to Humans -- 4.1. Predicted Environmental Concentrations versus Acceptable Daily Intakes -- 4.2. Measured Environmental Concentrations versus Acceptable Daily Intakes -- 4.3. Genotoxicity -- 4.4. Hormonal Disruption -- 4.5. Susceptible Sub-populations -- 4.6. Conclusions on Human Risks -- 5. Potential Risks to Aquatic Life.
505	0		_aNote continued: 5.1. Limitations of Available Ecotoxicity Data -- 5.2. Predicted Environmental Concentrations versus Predicted No Effect Concentrations -- 5.3. Measured Environmental Concentrations versus Predicted No Effect Concentrations -- 5.4. Estrogenic APIs -- 5.5. Antidepressants -- 5.6. Plasma Concentration Model -- 5.7. Conclusions on Risks to Aquatic Life -- 6. Antibiotics, Clinical Resistance and Potential Risks to Beneficial Microbes -- References -- Impacts of Pharmaceuticals on Terrestrial Wildlife / Chad A. Kinney -- 1. Introduction -- 1.1.A Global Context -- 1.2. Scale and Pathways -- 1.3. Recognised Impacts on Non-target Wildlife -- 1.4. Aim of this Chapter -- 2. Pathways, Exposure and Effects in Terrestrial Wildlife -- 2.1. Pathways, Exposure and Effects Associated with Freshwater Contamination -- 2.2. Pathways, Exposure and Effects within the Terrestrial Landscape -- 3. Known Impacts in Terrestrial Wildlife.
505	0		_aNote continued: 3.1. Case Study: Non-steroidal Anti-inflammatory Drugs and Avian Scavengers -- 4. Analytical and Monitoring Approaches and Challenges -- 4.1. Analytical Tools -- 4.2. Monitoring Approaches -- Transformation Products -- 4.3. Wildlife Exposure: Novel Biomarkers and Endpoints -- 4.4. Field Monitoring and Sample Matrices -- 5. Legislative Perspectives -- 5.1. Case 1: Scavenging Wildlife and Pentobarbital in the US -- 5.2. Case 2: Veterinary NSAIDs in the EU, South Africa and on the Indian Subcontinent -- 6. Future Priorities -- 6.1. Better Quantify Potential Risks for Terrestrial Wildlife -- 6.2. Improve Risk Assessment for Terrestrial Environments -- 6.3. Better Understand the Risks Posed by Pharmaceutical Transformation Products -- 6.4. Develop New Ways of Monitoring Across a Wider Range of Taxa -- 7. In Conclusion -- References -- Veterinary Pharmaceuticals / Silke Hickmann -- 1. Introduction.
505	0		_aNote continued: 2. Legal and Regulatory Demands Concerning Environmental Impact of VMPs in the EU -- 3. The Impact of VMPs on the Environment -- 3.1. Emission of VMP Residues Related to Production -- 3.2. Emission of VMPs Residues Related to Use -- 3.3. Emission of VMPs Residues Related to Disposal -- 4. Specific Toxic Effects of VMPs -- 4.1. Antiparasitics in the Aquatic Environment -- 4.2. Antimicrobials in Aquatic and Terrestrial Environments -- 4.3. Antiparasitics for Pasture Animals -- 4.4. Risks to Vultures and other Necrophagous Bird Populations in the European Union in Connection with the Use of Veterinary Medicines Containing Diclofenac -- 5. Monitoring and Ecopharmacovigilance -- References.
520			_a'Medicines play an important role in the treatment and prevention of disease in humans and animals, but residues from these medicines can be released into the environment through a number of routes during their manufacture, use and disposal. It is only recently that the potential environmental impacts of this exposure to pharmaceuticals are being considered. The book explores where pharmaceutical residues can be found, e.g. in surface waters, drinking water, sediments and the marine environment; the sources of these residues, from manufacture through to disposal of unused medicines; how these residues break down; and how this all impacts on wildlife and human health. In reviewing the current position and examining further possible impacts, this book is an important reference for researchers working in the pharmaceutical industry, as well as for environmentalists, policy makers and students on pharmacy and environmental science courses wanting to better understand the impacts of pharmaceuticals on the environment.'-- _cBack cover.
650		0	_aDrugs _xEnvironmental aspects.
650		0	_aPharmaceutical chemistry.
700	1		_aHester, R. E. _q(Ronald E.), _eeditor.
700	1		_aHarrison, Roy M., _d1948-, _eeditor.
830		0	_aIssues in environmental science and technology, _x1350-7583 ; _v41
907			_a.b16327184 _b2019-11-12 _c2019-11-12
942			_c01 _n0 _kTD196.D78P428
914			_avtls003606387
990			_abety
991			_aFakulti Sains dan Teknologi
998			_at _b2016-03-05 _cm _da _feng _genk _y0 _z.b16327184
999			_c610131 _d610131