| 000 | 03136cam a2200457 i 4500 | ||
|---|---|---|---|
| 005 | 20250919011706.0 | ||
| 008 | 160405t20152015flua b 001 0 eng | ||
| 020 |
_a9781466594869 _qhardcover _cRM631.59 |
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| 020 |
_a1466594861 _qhardcover |
||
| 039 | 9 |
_a201608041002 _basrul _c201608040912 _dasrul _c201607191028 _drasyilla _y04-05-2016 _zrasyilla |
|
| 040 |
_aDLC _beng _cDLC _erda _dDLC _dUKM _erda |
||
| 090 | _aQP86.V359 | ||
| 090 |
_aQP86 _b.V359 |
||
| 100 | 1 |
_aValentine, R. C. _q(Raymond Carlyle), _d1936-, _eauthor. |
|
| 245 | 1 | 0 |
_aHuman longevity : _bomega-3 fatty acids, bioenergetics, molecular biology, and evolution / _cRaymond C. Valentine and David L. Valentine. |
| 264 | 1 |
_aBoca Raton : _bCRC Press, Taylor & Francis Group, _c[2015]. |
|
| 264 | 4 | _c©2015. | |
| 300 |
_axvii, 223 pages : _billustrations (some color) ; _c24 cm. |
||
| 336 |
_atext _2rdacontent |
||
| 337 |
_aunmediated _2rdamedia |
||
| 338 |
_avolume _2rdacarrier |
||
| 504 | _aIncludes bibliographical references and index. | ||
| 520 |
_a'Human cells are protected from the ravages of aging by defensive systems including novel mechanisms against membrane oxidation introduced in this book. The book proposes a unified concept in which aging cells faced with declining energy production by mitochondria and the relatively high cost of protecting membranes against oxidation are triggered by energy stress to activate programmed cellular death. It includes case histories illustrating the duality of polyunsaturated membranes in aging and longevity. It also explains the relationship between membrane unsaturation and longevity leading to a unified concept of aging.'-- _cProvided by publisher. |
||
| 520 |
_a'This book is built on the proposition that we age as our mitochondria age. We suggest a revised version of Harman's famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. It is well known that cellular death or apoptosis is triggered by energy stress or oxidative stress. There is convincing data showing that as mitochondria age mitochondrial DNA (mtDNA) accumulates mutations decreasing energy output. Protecting highly unsaturated mitochondrial membranes against oxidative stress also consumes an extraordinary amount of energy'-- _cProvided by publisher. |
||
| 650 | 0 |
_aAging _xGenetic aspects. |
|
| 650 | 0 | _aMitochondria. | |
| 650 | 0 | _aOxidative stress. | |
| 650 | 0 |
_aOmega-3 fatty acids _xHealth aspects. |
|
| 650 | 7 |
_aMEDICAL / Biochemistry. _2bisacsh |
|
| 650 | 7 |
_aSCIENCE / Life Sciences / Biology / Molecular Biology. _2bisacsh |
|
| 650 | 7 |
_aTECHNOLOGY & ENGINEERING / Food Science. _2bisacsh |
|
| 700 | 1 |
_aValentine, David L., _eauthor. |
|
| 907 |
_a.b16301006 _b2019-11-12 _c2019-11-12 |
||
| 942 |
_c01 _n0 _kQP86.V359 |
||
| 914 | _avtls003603469 | ||
| 990 | _aasr | ||
| 991 | _aFakulti Sains dan Teknologi | ||
| 998 |
_at _b2016-05-04 _cm _da _feng _gflu _y0 _z.b16301006 |
||
| 999 |
_c607656 _d607656 |
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