000			04608nam a2200397Ia 4500
005			20250918191405.0
008			130604s2012 ne ob 001 0 eng d
020			_a9789400748187 (hbk.) _cRM649.28
039		9	_a201312091522 _brosli _c201312030854 _dros _c201312030852 _dros _y06-04-2013 _zros
040			_dUKM
090			_aRC267.S97
090			_aRC267 _b.S97
245	0	0	_aSystems biology in cancer research and drug discovery / _cAsfar S. Azmi, editor.
260			_aDordrecht : _bSpringer, _c2012.
300			_a1 online resource.
504			_aIncludes bibliographical references and index.
505	0	0	_gpt. 1. _tSystems Biology in Cancer. _tSystems Biology Approach to Metabolomics in Cancer Studies / _rMariano Bizzarri, Simona Dinicola and Cesare Manetti -- _tSystem Biology Approach to Study Cancer Related Pathways / _rYike Guo and Xian Yang -- _tModeling Oncogenic Signaling Networks from Gene Expression Dynamics / _rAliccia Bollig-Fischer -- _tAn Integrated Systems Approach to the Study of Pancreatic Cancer / _rEmanuela Gadaleta, Rosalind J. Cutts, Ajanthah Sangaralingam, Nicholas R. Lemoine and Claude Chelala -- _tProtein Microarray: An Ideal Platform for Systems Biology / _rZong-Xiu Wang, Rui-Ping Deng, Shu-Juan Guo, Ji-Bin Zhang and Sheng-Ce Tao -- _tSystems Biology of Pancreatic Cancer: The Role of Tumor-Microenvironment Communication in Development, Progression and Therapy Resistance / _rSara Chiblak, Fevzi Demircioglu, Azadeh Fahim Golestaneh and Amir Abdollahi .
505	0	0	_gpt. 2. _tSystem Approaches to Understanding Cancer. _tUnderstanding Cancer Progression Using Protein Interaction Networks / _rEmre Guney, Rebeca Sanz-Pamplona, Angels Sierra and Baldo Oliva -- _tUnderstanding the Dynamics of Tumor Angiogenesis: A Systems Biology Approach / _rM. M. Quinas-Guerra, T. M. Ribeiro-Rodrigues, Juan Carlos Rodruez-Manzaneque and Rui D. M. Travasso -- _tApplications of Network Bioinformatics to Cancer Angiogenesis / _rCorban G. Rivera, Liang-Hui Chu, Joel S. Bader and Aleksander S. Popel .
505	0	0	_gpt. 3. _tSystems and Network Biology in Decoding miRNA Complexity. _tHuman MicroRNA Targetome Indicates a Specialized Role of MicroRNAs in Regulation of Oncogenesis / _rJun-ichi Satoh -- _tNovel and Alternative Bioinformatics Approaches to Understand miRNA-mRNA Interactome in Cancer Research / _rXiaohong Li, Carolyn M. Klinge and Susmita Datta -- _tPrioritizing Candidate Disease miRNAs by Topological Features in the miRNA-Target Dysregulated Network / _rXia Li, Juan Xu and Yongsheng Li .
505	0	0	_gpt. 4. _tNetwork Modeling in Cancer Drug Discovery and Clinical Trials. _tDevelopment and Clinical Implementation of Reverse Phase Protein Microarrays for Protein Network Activation Mapping: Personalized Cancer Therapy / _rMariaelena Pierobon, Julie Wulfkuhle, Lance A. Liotta and Emanuel F. Petricoin III -- _tThe Principle of Rational Design of Drug Combination and Personalized Therapy Based on Network Pharmacology / _rJianghui Xiong, Simon Rayner, Fengji Liang and Yinghui Li -- _tRelevance of Network Hierarchy in Cancer Drug-Target Selection / _rAritro Nath and Christina Chan -- _tComputational Infrastructures for Large-Scale Data Access and Analysis in Post-Genomic Clinical Trials / _rManolis Tsiknakis -- _tNetwork Pharmacology: An Emerging Area in Anti-Cancer Drug Discovery / _rAsfar S. Azmi, Frances W. J. Beck, Bin Bao, Fazlul H. Sarkar and Ramzi M. Mohammad.
520			_a''Systems Biology in Cancer Research and Drug Discovery'' provides a unique collection of chapters, by world-class researchers, describing the use of integrated systems biology and network modeling in the cancer field where traditional tools have failed to deliver expected promise. This book touches four applications/aspects of systems biology in understanding aberrant signaling in cancer; in identifying biomarkers and prognostic markers especially focused on angiogenesis pathways; in unwinding microRNAs complexity; and in anticancer drug discovery and in clinical trial design. This book revie
650		0	_aCancer _xResearch.
650		0	_aSystems Biology.
650		0	_aDrug development.
650		0	_aDrugs _xDesign.
650		0	_aPharmacy _xTechnological innovations.
700	1		_aAzmi, Asfar S.
907			_a.b15650479 _b2019-11-12 _c2019-11-12
942			_c01 _n0 _kRC267.S97
914			_avtls003531546
990			_ark4
991			_aFakulti Kejuruteraan dan Alam Bina
998			_al _b2013-04-06 _cm _da _feng _gne _y0 _z.b15650479
999			_c547776 _d547776