| 000 | 02415cam a22003254a 4500 | ||
|---|---|---|---|
| 005 | 20250918150707.0 | ||
| 008 | 120228s2010 flua b 001 0 eng | ||
| 020 |
_a9781420073492 _cRM409.12 |
||
| 020 | _a1420073494 | ||
| 039 | 9 |
_a201204271522 _bzainol _y02-28-2012 _zrazalis |
|
| 040 | _aUKM | ||
| 090 | _aQT36.K61z 2010 9 | ||
| 090 |
_aQT36 _b.K61z 2010 9 |
||
| 100 | 1 |
_aKisaalita, William Ssempa, _d1953- |
|
| 245 | 1 | 0 |
_a3D cell-based biosensors in drug discovery programs : _bmicrotissue engineering for high throughput screening / _cWilliam S. Kisaalita. |
| 246 | 3 | _aThree-dimensional cell-based biosensors in drug discovery programs | |
| 260 |
_aBoca Raton : _bCRC Press, _c2010. |
||
| 300 |
_axvii, 386 p. : _bill. ; _c25 cm. |
||
| 505 | 0 | _aBiosensors and bioassays -- Target-driven drug discovery -- Comparative transcriptional profiling and proteomics -- Comparative structure and function -- Chemical microenvironmental factors -- Spatial and temporal microenvironmental factors -- Material physical property and force microenvironmental factors -- Proteomics as a promising tool in the search for 3D biomarkers -- Readout present and near future -- Ready-to-use commercial 3D plates -- Challenges to adopting 3D cultures in HTS programs -- Cases for 3D cultures in drug discovery -- Ideal case study design. | |
| 520 | _a'This book is based upon cutting-edge research conducted in the authors lab (Cellular Bioengineering), which over the past decade has developed a number of sophisticated techniques to facilitate use of 3D cell based assays or biosensors. This book uses data from peer-reviewed publications to conclusively justify use of 3D cell cultures in cell-based biosensors (assays) for (HTS). The majority of assays performed in accelerated drug discovery processes are biochemical in nature, but there is a growing demand for live cell-based assays. Unlike biochemical ones, cellular assays are functional approximations of in vivo biological conditions and can provide more biologically relevant information'--Provided by publisher. | ||
| 650 | 2 |
_aBiosensing Techniques _xmethods. |
|
| 650 | 2 | _aCells, Cultured. | |
| 650 | 2 | _aDrug Discovery. | |
| 907 |
_a.b15254550 _b2021-05-28 _c2019-11-12 |
||
| 942 |
_c01 _n0 _kQT36.K61z 2010 9 |
||
| 914 | _avtls003489083 | ||
| 991 | _aFakulti Farmasi, KKL | ||
| 998 |
_ad _b2012-02-02 _cm _da _feng _gflu _y0 _z.b15254550 |
||
| 999 |
_c509531 _d509531 |
||