000			04049cam a2200325 a 4500
005			20250918004502.0
008			090325s2008 fluaf b 001 0 eng
020			_a9780849387968 (alk. paper)
020			_a0849387965 (alk. paper) _cRM715.01
039		9	_a200904201448 _bruzini _y03-25-2009 _zrazalis
040			_aUKM
060			_aQU57 _b.A6324 2008 9
090			_aQU57.A6324 2008 9
245	0	0	_aAntisense drug technology : _bprinciples, strategies, and applications / _cedited by Stanley T. Crooke
250			_a2nd ed.
260			_aBoca Raton : _bCRC Press, _c2008
300			_axvii, 825 p., [12] p. of plates : _bill. (some col.) ; _c27 cm.
504			_aIncludes bibliographical references and index
505	0		_aMechanisms of antisense drug action, an introduction / Stanley T. Crooke ... [et al.] -- The RNase H mechanism / Walt Lima, Hongjiang Wu, and Stanley T. Crooke -- Small RNA silencing pathways / Alla Sigova and Phillip D. Zamore -- Splice switching oligonucleotides as potential therapeutics / Peter Sazani, Maria A. Graziewicz, and Ryszard Kole -- Basic principles of antisense drug discovery / Susan M. Freier and Andrew T. Watt -- The medicinal chemistry of oligonucleotides / Eric E. Swayze and Balkrishen Bhat -- Basic principles of the pharmacokinetics of antisense oligonucleotide drugs / Arthur A. Levin, Rosie Z. Yu, and Richard S. Geary -- Routes and formulations for delivery of antisense oligonucleotides / Gregory E. Hardee, Lloyd G. Tillman, and Richard S. Geary -- Liposomal formulations for nucleic acid delivery / Ian MacLachlan -- Pharmacological properties of 2'-O-methoxyethyl-modified oligonucleotides / C. Frank Bennett -- Pharmacokinetic/pharmacodynamic properties of phosphorothioate 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides in animals and man / Richard S. Geary ... [et al.] -- Toxicologic properties of 2'-O-methoxyethyl chimeric antisense inhibitors in animals and man / Scott P. Henry ... [et al.] -- An overview of the clinical safety experience of first- and second-generation antisense oligonucleotides / T. Jesse Kwoh -- Manufacturing and analytical processes for 2'-O-(2-methoxyethyl)-modified oligonucleotides / Daniel C. Capaldi and Anthony N. Scozzari -- Utilizing chemistry to harness RNA interference pathways for therapeutics : chemically modified siRNAs and antagomirs / Muthiah Manoharan and Kallanthottathil G. Rajeev --
505	0		_aDiscovery and development of RNAi therapeutics / Antonin R. deFougerolles and John M. Maraganore -- Optimization of second-generation antisense drugs: going beyond generation 2.0 / Brett P. Monia ... [et al.] -- Modulating gene function with peptide nucleic acids (PNA) / Peter E. Nielsen -- Locked nucleic acid / Troels Koch and Henrik rum -- Morpholinos / Patrick L. Iversen -- Potential therapeutic applications of antisense oligonucleotides in ophthalmology / Lisa R. Grillone and Scott P. Henry -- Cardiovascular therapeutic applications / Rosanne M. Crooke, Brenda Baker, and Mark Wedel -- Developing antisense drugs for metabolic diseases: a novel therapeutic approach / Sanjay Bhanot -- Inflammatory diseases / Susan A. Gregory and James G. Karras -- Antisense oligonucleotides for the treatment of cancer / Boris A. Hadaschik and Martin E. Gleave -- Targeting neurological disorders with antisense oligonucleotides / Richard A. Smith and Timothy M. Miller -- Mechanisms and therapeutic applications of immune modulatory oligodeoxynucleotide and oligoribonucleotide ligands for toll-like receptors / Jorg Vollmer and Arthur M. Krieg -- Aptamer opportunities and challenges / Charles Wilson
650		2	_aOligonucleotides, Antisense _xtherapeutic use
700	1		_aCrooke, Stanley T.
856	4	1	_3Table of contents only _uhttp://www.loc.gov/catdir/toc/ecip076/2006101712.html
907			_a.b14445487 _b2019-11-12 _c2019-11-12
942			_c01 _n0 _kQU57.A6324 2008 9
914			_avtls003403817
991			_aJabatan Farmasi, KKL
998			_ad _b2009-12-03 _cm _da _feng _gflu _y0 _z.b14445487
999			_c437082 _d437082