Biomedical technology : modeling, experiments and simulation / Peter Wriggers, Thomas Lenarz, editors.

Includes bibliographical references.

Vendor-supplied metadata.

Preface; Contents; Part I Biological Systems; Multiscale Aspects in the Multiphasic Modelling of Human Brain Tissue ; 1 Introduction and Motivation; 2 Anatomic Elements of Human Brain Tissue; 3 TPM Model of the Overall Brain-Tissue Aggregate; 4 Microscopically Underlaid Macroscopic Constitutive Relation; 4.1 Microscopic Model Settings; 4.2 Macroscopic Constitutive Relation; 4.3 Results and Discussion; References; Simulation of Steatosis Zonation in Liver Lobule -- A Continuummechanical Bi-Scale, Tri-Phasic, Multi-Component Approach; 1 Introduction; 2 Glucose and Fat Metabolism

3 Numerical Example: Comparison of Different Assumptions for the Perfusion Coupled to the Metabolism3.1 Discussion; References; 3 Nano-Mechanical Tensile Behavior of the SPTA1 Gene in the Presence of Hereditary Hemolytic Anemia-Related Point Mutations; Abstract; 1 Introduction; 2 Spectrin Structure; 3 Materials and Methods; 4 Results; 5 Discussion; Acknowledgements; References; The Choice of a Performance Indicator of Release in Transdermal Drug Delivery Systems ; 1 Introduction; 2 The Concept of an Effective Time Constant: Definition and Applications; 3 A One-Layer Model for TDD

4 Computation of the ETC for a One-Layer Skin Model5 A Multi-layer Model for TDD; 6 Computation of the ETC for a Multi-layer Skin Model; 7 Computational Results; 8 Conclusions; References; Part II Cardiovascular Medicine; 5 Multiscale Multiphysic Approaches in Vascular Hemodynamics; Abstract; 1 Introduction; 2 Geometry Creation and General Simulation Settings; 3 Boundary Conditions; 3.1 Lumped Parameter Modeling; 3.2 0-D/3-D Coupling; 4 Fluid-Structure-Interaction; 4.1 0-D/3-D Coupling of FSI Simulations; 5 Examples; 5.1 An FSI Model of Cardiopulmonary Bypass with Cerebral Autoregulation

5.2 A CFD Model of VAD Support Using Closed-Loop Multiscale Simulations to Evaluate Various Cannulation Strategies5.3 A Numerical Framework to Investigate Hemodynamics During Endovascular Mechanical Recanalization in Acute Stroke; 6 Conclusion; References; Heart Valve Flow Computation with the Space -- Time Slip Interface Topology Change (ST-SI-TC) Method and Isogeometric Analysis (IGA); 1 Introduction; 2 ST-VMS and ST-SI Formulations; 2.1 ST-VMS Formulation; 2.2 ST-SI Formulation; 3 ST-SI-TC-IGA Method; 3.1 ST-SI Method; 3.2 ST-TC Method; 3.3 ST-IGA Method

3.4 Integration of the ST-SI, ST-TC and ST-IGA Methods4 Aortic-Valve Model; 4.1 Geometry; 4.2 Mesh and Flow Conditions; 4.3 Computational Conditions; 4.4 Results; 5 Concluding Remarks; References; Estimation of Element-Based Zero-Stress State in Arterial FSI Computations with Isogeometric Wall Discretization ; 1 Introduction; 2 Element-Based Total Lagrangian (EBTL) Method; 2.1 EBZSS; 2.2 NURBS Basis Functions; 2.3 EBZSS Representation with NURBS Basis Functions; 3 Modeling the Artery ZSS: Straight-Tube ZSS Template; 4 2D Test Computations; 4.1 Meshes; 4.2 Curvature Matching in the ZSS

This book provides an overview of new mathematical models, computational simulations and experimental tests in the field of biomedical technology, and covers a wide range of current research and challenges. The first part focuses on the virtual environment used to study biological systems at different scales and under multiphysics conditions. In turn, the second part is devoted to modeling and computational approaches in the field of cardiovascular medicine, e.g. simulation of turbulence in cardiovascular flow, modeling of artificial textile-reinforced heart valves, and new strategies for reducing the computational cost in the fluid-structure interaction modeling of hemodynamics. The book’s last three parts address experimental observations, numerical tests, computational simulations, and multiscale modeling approaches to dentistry, orthopedics and otology. Written by leading experts, the book reflects the remarkable advances that have been made in the field of medicine, the life sciences, engineering and computational mechanics over the past decade, and summarizes essential tools and methods (such as virtual prototyping of medical devices, advances in medical imaging, high-performance computing and new experimental test devices) to enhance medical decision-making processes and refine implant design. The contents build upon the International Conference on Biomedical Technology 2015 (ICTB 2015), the second ECCOMAS thematic conference on Biomedical Engineering, held in Hannover, Germany in October 2015.

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