TY  - BOOK
AU  - El-Kattan,Ayman F.
TI  - Oral bioavailability assessment: basics and strategies for drug discovery and development 
SN  - 9781118916926
AV  - RS403 
U1  - 615.1/9 23
PY  - 2017///
CY  - Hoboken, NJ
PB  - John Wiley & Sons Inc.
KW  - Dental pharmacology
KW  - MEDICAL / Pharmacology
KW  - bisacsh
KW  - fast
KW  - Biological availability
KW  - Drug Evaluation, Preclinical
KW  - Toxicokinetics
KW  - Administration, Oral
KW  - Electronic books
N1  - Includes bibliographical references and index; Drug pharmacokinetics and toxicokinetics -- GIT anatomy and physiology and drug oral bioavailability : impact of species differences -- Drug routes of excretion -- Physicochemical and biopharmaceutical properties that affect drug absorption of compounds absorbed by passive diffusion -- Physicochemical and biopharmaceutical factors affecting hepatic/intestinal first pass effect -- Impact of intestinal efflux transporters on oral absorption -- Impact of influx transporters on drug -- Extended Clearance Classification System (ECCS) and its utility in predicting clearance rate determining step in drug discovery -- In vitro and in situ approaches to measure intestinal permeability and efflux transporters -- In silico approaches to predict intestinal permeability -- In vivo preclinical approaches to deconvolute the contribution of first pass effect from oral absorption -- In vitro approaches to assess haptic metabolism and first pass effect -- The utility of ECCS as a roadmap to improve oral bioavailability of new molecular entities : industrial perspective
UR  - https://eresourcesptsl.ukm.remotexs.co/user/login?url=https://doi.org/10.1002/9781118916926
ER  -