TY - BOOK AU - Alper,Hal S. TI - Systems metabolic engineering: methods and protocols T2 - Methods in molecular biology SN - 9781627032988 (hbk.) PY - 2013/// CY - New York PB - Humana Press KW - Metabolism KW - Biomedical engineering KW - Systems Biology N1 - Includes bibliographical references and index; Genome-scale model management and comparison; Stephan Pabinger and Zlatko Trajanoski --; Automated genome annotation and metabolic model reconstruction in the SEED and model SEED; Scott Devoid ... [et al.] --; Metabolic model refinement using phenotypic microarray data; Pratish Gawand ... [et al.] --; Linking genome-scale metabolic modeling and genome annotation; Edik M. Blais, Arvind K. Chavali, and Jason A. Papin --; Resolving cell composition through simple measurements, genome-scale modeling, and a genetic algorithm; Ryan S. Senger and Hadi Nazem-Bokaee --; Guide to integrating transcriptional regulatory and metabolic networks using PROM (probabilistic regulation of metabolism); Evangelos Simeonidis, Sriram Chandrasekaran, and Nathan D. Price --; Kinetic modeling of metabolic pathways : application to serine biosynthesis; Kieran Smallbone and Natalie J. Stanford --; Computational tools for guided discovery and engineering of metabolic pathways; Matthew Moura, Linda Broadbelt, and Keith Tyo --; Retrosynthetic design of heterologous pathways; Pablo Carbonell, Anne-Gaelle Planson, and Jean-Loup Faulon --; Customized optimization of metabolic pathways by combinatorial transcriptional engineering; Yongbo Yuan, Jing Du, and Huimin Zhao --; Adaptive laboratory evolution for strain engineering; James Winkler, Luis H. Reyes, and Katy C. Kao --; Trackable multiplex recombineering for gene-trait mapping in E. coli; Thomas J. Mansell, Joseph R. Warner, and Ryan T. Gill --; Identification of mutations in evolved bacterial genomes; Liam Royce ... [et al.] --; Discovery of posttranscriptional regulatory RNAs using next generation sequencing technologies; Grant Gelderman and Lydia M. Contreras --; 13C-based metabolic flux analysis : fundamentals and practice; Tae Hoon Yang --; Nuclear magnetic resonance methods for metabolic fluxomics; Shilpa Nargund ... [et al.] --; Using multiple tracers for 13C metabolic flux analysis; Maciek R. Antoniewicz --; Isotopically nonstationary 13C metabolic flux analysis; Lara J. Jazmin and Jamey D. Young --; Sample preparation and biostatistics for integrated genomics approaches; Hein Stam ... [et al.] --; Targeted metabolic engineering guided by computational analysis of single-nucleotide polymorphisms (SNPs); D.B.R.K. Gupta Udatha ... [et al.] --; Linking RNA measurements and proteomics with genome-scale models; Christopher M. Gowen and Stephen S. Fong --; Comparative transcriptome analysis for metabolic engineering; Shuobo Shi, Tao Chen, and Xueming Zhao --; Merging multiple omics datasets in silico : statistical analyses and data interpretation; Kazuharu Arakawa and Masaru Tomita ER -