TY - BOOK AU - Rowland,Malcolm AU - Tozer,Thomas N. AU - Rowland,Malcolm TI - Clinical pharmacokinetics and pharmacodynamics: concepts and applications SN - 9780781750097 PY - 2011/// CY - Philadelphia PB - Lippincott William & Wilkins KW - Pharmacokinetics KW - Drug Therapy N1 - This book includes online access at http://thepoint.lww.com/Rowland4e, please refer to library staff for the password; Therapeutic relevance -- Fundamental concepts and terminology -- Kinetics following an intravenous bolus dose -- Membranes and distribution -- Elimination -- Kinetics following an extravascular dose -- Absorption -- Response following a single dose -- Therapeutic window -- Constant-rate input -- Multiple dose regimens -- Variability -- Genetics -- Age, weight, and gender -- Disease -- Nonlinearities -- Drug interactions -- Initiating and managing therapy -- Distribution kinetics -- Metabolites and drug response -- Protein drugs -- Prediction and refinement of human kinetics from in vitro, preclinical, and early clinical data ER -