Clinical pharmacokinetics and pharmacodynamics : concepts and applications - Rowland, Malcolm; Tozer, Thomas N.; Rowland, Malcolm (Philadelphia : Lippincott William & Wilkins, 2011)
Therapeutic relevance -- Fundamental concepts and terminology -- Kinetics following an intravenous bolus dose -- Membranes and distribution -- Elimination -- Kinetics following an extravascular dose -- Absorption -- Response following a single dose -- Therapeutic window -- Constant-rate input -- Multiple dose regimens -- Variability -- Genetics -- Age, weight, and gender -- Disease -- Nonlinearities -- Drug interactions -- Initiating and managing therapy -- Distribution kinetics -- Metabolites and drug response -- Protein drugs -- Prediction and refinement of human kinetics from in vitro, preclinical, and early clinical data.
This book includes online access at http://thepoint.lww.com/Rowland4e, please refer to library staff for the password.
Keywords: Pharmacokinetics; Drug Therapy