In silico technologies in drug target identification and validation - Leon, Darryl; Markel, Scott (Boca Raton : CRC Press, 2006)
Pattern matching / Scott Markel and Vinodh N. Rajapakse -- Tools for computational protein annotation and function assignment / Jaume M. Canaves -- The impact of genetic variation on drug discovery and development / Michael R. Barnes -- Mining of gene-expression data / Aedin Culhane and Alvis Brazma -- Text mining / Bruce Gomes, William Hayes, and Raf M. Podowski -- Pathways and networks / Eric Minch and Ivayla Vatcheva -- Molecular interactions: learning from protein complexes / Ana Rojas, David de Juan and Alfonso Valencia -- In silico siRNA design / Darryl Leon -- Predicting protein subcellular localization using intelligent systems / Rajesh Nair and Burkhard Rost -- The third-dimensional structures in target discovery and validation / Sean I. O'Donoghue, Robert B. Russell, and Andrea Schafferhans -- Comparative genomics / Viviane Siino, Bruce Pascal, and Christopher Sears -- Pharmacogenomics / Bahram Ghaffarzadeh Kermani -- Target identification and validation using human simulation models / Seth Michelson, Didier Scherrer, and Alex L. Bangs -- Using protein targets for in silico structure-based drug discovery / Tad Hurst -- Database management / Arek Kasprzyk, and Damian Smedley -- BioIT hardware configuration / Philip Miller -- BioIT architecture: Software architecture for bioinformatics research / Michael Dickson -- Workflows and data pipelines / Mike Peeler -- Ontologies / Robin A. McEntire and Robert Stevens
Includes bibliographical references and index
Keywords: Drug delivery systems -- methods; Chemistry, Pharmaceutical; Computational Biology