Antibiotics : actions, origins, resistance - Walsh, Christopher (Washington : ASM Press, 2003)
Antibiotics: initial concepts -- Introduction to major antibiotic classes and modes of action -- Antibiotics that act on cell wall biosynthesis -- Antibiotics that block bacterial protein biosynthesis -- Antibiotics that block DNA replication and repair: the quinolones -- Other targets of antibacterial drugs -- Natural and producer immunity versus acquired resistance -- Enzymatic destruction or modification of the antibiotic by resistant bacteria -- Antibiotic resistance by efflux pumps -- Antibiotic resistance by replacement or modification of the antibiotic target -- Regulation of antibiotic biosynthesis in producer organisms -- Polyketide antibiotic biosynthesis: assembly-line enzymology -- Enzymatic assembly lines for nonribosomal peptide antibiotics -- Biosynthesis of other classes of antibiotics -- New looks at targets -- New molecules -- Contexts and challenges for the use of new antibiotics
References : p. 297-328
Keywords: Antibiotics -- pharmacology; Drug Resistance, Bacterial