TY - BOOK AU - Koshland,Daniel E. ED - Open University Educational Enterprises TI - The properties of enzymes II ( motion picture): cooperativity PY - 1978/// CY - Milton Keynes PB - The Open University Press KW - Enzymes N1 - Prof. Koshland explained cooperativity and the sigmoid curve in terms of the models illustrated in Fig.1. These two theories rest on quite different assumptions. The sequential model proposed by Prof. Koshland & his co-workers depends upon the property of flexibility. The symmetry model of Monod, Wyman & Changenx requires that all subunits in the molucle are in the same confirmational form; Backup available in VHS 1/2 in ER -