The properties of enzymes II ( motion picture) : cooperativity - Koshland, Daniel E.; Open University Educational Enterprises (Milton Keynes : The Open University Press, 1978)
Prof. Koshland explained cooperativity and the sigmoid curve in terms of the models illustrated in Fig.1. These two theories rest on quite different assumptions. The sequential model proposed by Prof. Koshland & his co-workers depends upon the property of flexibility. The symmetry model of Monod, Wyman & Changenx requires that all subunits in the molucle are in the same confirmational form.
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Keywords: Enzymes