Drug-drug interactions in pharmaceutical development / edited by Albert P. Li

Includes bibliographical references and index

In vitro evaluation of metabolic drug-drug interactions: concepts and practice / Albert P. Li -- In vitro approaches to anticipating clinical drug interactions / Laurie P. Volak, David J. Greenblatt, and and Lisa L. von Moltke -- Inhibition of drug-metabolizing enzymes and drug-drug interactions in drug discovery and development / R. Scott Obach -- Mechanism-based CYP inhibition: enzyme kinetics, assays, and prediction of human drug-drug interactions / Magang Shou -- Genomic approaches to drug-drug interactions / Yi Yang and Jeffrey F. Waring -- Transporters and drug interactions / Yoshihisa Shitara, Toshiharu Horie, and Yuichi Sugiyama -- Transporter-mediated drug interactions: molecular mechanisms and clinical implications / Jiunn H. Lin -- Recent case studies of clinically significant drug-drug interactions and the limits of in vitro prediction methodology / Rene H. Levy, Isabelle Ragueneau-Majlessi, Carol Collins -- U.S. regulatory perspective: drug-drug interactions / John Strong and Shiew-Mei Huang -- Herbal drug interactions: a Canadian perspective / Brian C. Foster