Genetic variance detection : nuts & bolts of DHPLC in genomics / edited by Karl Heinz Hecker

Includes bibliographical references and index.

Basics of automated, high-accuracy mutation screening with the WAVE Nucleic Acid Fragment Analysis Systems / Karl H. Hecker -- Influence of PCR on DHPLC polymorphism characterization / Michael L. Nickerson -- Denaturing high performance liquid chromatography (DHPLC), an important mutation detection technique in mutation analysis of the breast and ovarian cancer predisposing genes BRCA1 and BRCA2 / Norbert Arnold and Dieter Niederacher -- Mutation detection in the tuberous sclerosis genes TSC1 and TSC2 by DHPLC / Penelope S. Roberts, Sandra L. Dabora, David J. Kwiatkowski -- Rapid analysis to detect base changes in human mitochondrial DNA by restriction enzyme analysis followed by denaturing high performance liquid chromatography / Patricia E. McAndrew and Michael A. Marino -- Mutation analysis of LDLR mutations in patients with familial hypercholesterolaemia / Caroline F. Bunn and Peter M. George -- Novel DHPLC based strategy for identification and characterization of (bi)-clonal T-cell receptor targets for the detection of minimal residual disease in childhood acute lymphoblastic leukemia / Udo zur Stadt ... [et al.] -- SIRPH : a rapid, quantitative SNuPE-IP RP HPLC method for simultaneous methylation analysis at multiple CpG sites / Osman El-Maarri, Johannes Oldenburg and Jorn Walter -- Isolation and sequencing of heteroduplex fragments from DHPCL analysis of somatic, low-frequency mutations / Jan Alsner -- Analysis of promoter methylation using denaturing high-performance liquid chromatography (DHPLC) / Beate Betz and Dieter Niederacher