MARC details
| 000 -LEADER |
|---|
| fixed length control field |
05626cam a22004578i 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20250919004745.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
150804s2015 njua b 001 0 eng |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9781118788356 (hardback) |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
1118788354 (hardback) |
| 039 #9 - LEVEL OF BIBLIOGRAPHIC CONTROL AND CODING DETAIL [OBSOLETE] |
|---|
| Level of rules in bibliographic description |
201511061131 |
| Level of effort used to assign nonsubject heading access points |
zainol |
| y |
08-04-2015 |
| z |
fashihah |
| 040 ## - CATALOGING SOURCE |
|---|
| Original cataloging agency |
UKM |
| Description conventions |
rda |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
WL200.B655 2015 9 |
| 090 ## - LOCALLY ASSIGNED LC-TYPE CALL NUMBER (OCLC); LOCAL CALL NUMBER (RLIN) |
|---|
| Classification number (OCLC) (R) ; Classification number, CALL (RLIN) (NR) |
WL200 |
| Local cutter number (OCLC) ; Book number/undivided call number, CALL (RLIN) |
.B655 2015 9 |
| 245 00 - TITLE STATEMENT |
|---|
| Title |
Blood-brain barrier in drug discovery : |
| Remainder of title |
optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs / |
| Statement of responsibility, etc. |
edited by Li Di, Edward H. Kerns. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Hoboken, New Jersey : |
| Name of producer, publisher, distributor, manufacturer |
John Wiley & Sons Inc., |
| Date of production, publication, distribution, manufacture, or copyright notice |
[2015] |
| 264 #4 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Date of production, publication, distribution, manufacture, or copyright notice |
@2015 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xiv, 586 pages ;: |
| Other physical details |
illustration ; |
| Dimensions |
24 cm. |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
unmediated |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
volume |
| Source |
rdacarrier |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographical references and index. |
| 505 8# - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
1. Introduction and overview / Li Di (Pfizer Inc.), Edward H. Kerns -- Pharmacokinetics of Brain Exposure -- 2. Pharmacokinetics of CNS penetration / Andreas Reichel (Bayer) -- 3. Free Drug Hyposthesis for CNS Drug Candidates / Xingrong Liu (Genentech) -- 4. Species Differences and impact of desease state on BBB / Jean-Marie Nicolas (UCB Pharma S.A.) -- Mechanisms of Drugs Across the Blood-Brain Barrier -- 5. Passive diffusion permeability of the BBB -- examples and SAR / Phil Jeffrey (GSK) -- 6. Efflux transport at the BBB -- examples and SAR / Jerome Hochman (Merck) -- 7. Uptake transport at the BBB -- examples and SAR / Zack Cheng (AstraZeneca) -- 8. Uptake of proteins and antibodies at the BBB / William Pardridge (UCLA) -- Predicting and Measuring Brain Exposure of Drugs -- 9. In silico tools for assessing brain exposure / Hongming Chen (AstraZeneca) -- 10. In vitro assays for assessing BBB permeability -- vascular cells, artificial membranes, brain slice, cell uptake / Winfried Neuhaus (University of Vienna) -- 11. Human-based in vitro endothelial cell models / Eric Shusta (University of Wisconsin) -- 12. In vitro assays for assessing brain binding / Li Di (Pfizer) -- 13. In vivo studies of brain exposure / Edward H. Kerns -- 14. PBPK models for BBB / Elizabeth de Lange (Leiden University) -- 15. PK/PD modeling of CNS drug candidates / Johan Gabrielsson (Swedish University) -- 16. Microdialysis to assess free drug concentration in brain / William Kielbasa (Lilly) -- 17. Imaging technique for CNS drug discovery / Lei Zhang (Pfizer Inc.) -- Modulating Brain Penetration of Leads During Drug Discovery -- 18. Designing CNS drugs for optimal brain exposure / Zoran Rankovic (Lilly) -- 19. Case studies of CNS drug optimization -- medicinal chemistry and CNS biology perspectives / Kevin J. Hodgetts (Harvard NeuroDiscovery Center) -- 20. Designing peripheral drugs for minimal brain exposue / Peter Bungay (Pfizer) -- 21. Case studies of non-CNS drugs to minimize brain penetration -- Nonsedative antihistamines / Andrew Crowe (Curtin University) -- Case Studies in CNS Drug Discovery -- 22. Case study 1 on discovery of a successful CNS drug -- Fycompa (AMPA Receptor Antagonist) / Andrew Satlin and Antonio Laurenza (Eisai) -- 23. Case study 2 on discovery of a successful CNS drug -- Vortioxetine (Serotonin Modulator and Stimulator) / Benny Bang-Andersen (Lundbeck) -- Drug Delivery Techniques to CNS -- 24. Brain delivery using nanotechnology / Xinguo Jiang (Fudan University) -- 25. Intranasal delivery to CNS / Lisbeth Illum (University of Nottingham) -- Future Prospective in Blood Brain Barrier Advancement -- 26. Future perspectives / Joan Abbott (King's College). |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
'Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant - and most challenging - areas of drug discovery. Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects. Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies. Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes. Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK). Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market'--Provided by publisher. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Blood-brain barrier |
| General subdivision |
Metabolism. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Central Nervous System Agents |
| General subdivision |
pharmacokinetics. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Blood-Brain Barrier |
| General subdivision |
drug effects. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Central nervous system diseases |
| General subdivision |
Drug therapy. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Drug Discovery |
| General subdivision |
methods. |
| 650 #2 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Drug-Related Side Effects and Adverse Reactions |
| General subdivision |
prevention & control. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Di, Li, |
| Relator term |
editor. |
| 700 1# - ADDED ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kerns, Edward Harvel, |
| Relator term |
editor. |
| 776 08 - ADDITIONAL PHYSICAL FORM ENTRY |
|---|
| Relationship information |
Online version: |
| Title |
Blood-brain barrier in drug discovery |
| Place, publisher, and date of publication |
Hoboken, New Jersey : John Wiley & Sons Inc., [2015] |
| International Standard Book Number |
9781118788493 |
| Record control number |
(DLC) 2014041569 |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
.b16188019 |
| b |
2019-11-12 |
| c |
2019-11-12 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Koha item type |
AM |
| Suppress in OPAC |
No |
| Call number prefix |
WL200.B655 2015 9 |
| 914 ## - VTLS Number |
|---|
| VTLS Number |
vtls003591152 |
| 990 ## - EQUIVALENCES OR CROSS-REFERENCES [LOCAL, CANADA] |
|---|
| Link information for 9XX fields |
zr |
| 991 ## - LOCAL NOTE (NAMA FAKULTI/INSTITUT/PUSAT) |
|---|
| a |
Program Sains Bioperubatan, Pusat Pengajian Sains Diagnostik dan Kesihatan Gunaan, FSK, KKL |
| 998 ## - LOCAL CONTROL INFORMATION (RLIN) |
|---|
| Library |
PERPUSTAKAAN DR ABDUL LATIFF |
| Operator's initials, OID (RLIN) |
2015-04-08 |
| Cataloger's initials, CIN (RLIN) |
m |
| Material Type (Sierra) |
Printed Books |
| Language |
English |
| Country |
|
| -- |
0 |
| -- |
.b16188019 |
