Biomarker validation : technological, clinical and commercial aspects /
Biomarker validation : technological, clinical and commercial aspects /
edited by Harald Seitz and Sarah Schumacher.
- 1 online resource.
Includes bibliographical references and index.
Related Titles; Title Page; Copyright; Table of Contents; List of Contributors; Chapter 1: Biomarkers -- Past and Future; 1.1 Introduction; 1.2 Definitions of Biomarkers; 1.3 Biomarkers in the Past; 1.4 Novel Molecules and Structural Classes of Biomarkers by New Technologies; 1.5 Biomarkers in Drug Research; 1.7 Summary and Outlook; References; Chapter 2: Quantitative Proteomics Techniques in Biomarker Discovery; 2.1 Introduction; 2.2 2D-Difference Gel Electrophoresis; 2.3 Mass Spectrometry-Based Proteomics; 2.4 MALDI Mass Spectrometry Imaging; 2.5 Conclusion; References Chapter 3: Biomarker Qualification: A Company Point of View3.1 Introduction; 3.2 Biomarker Uses; 3.3 Biomarker Types; 3.4 Validation vs. Qualification; 3.5 Strategic Choices in Business Models; 3.6 Validation of Analytical Methods; 3.7 Clinical Qualification of Candidate Biomarkers; 3.8 Biomarker Qualification in the'omics Era; 3.9 An Example of a Biomarker Provider; 3.10 Conclusion; References; Chapter 4: Biomarker Discovery and Medical Diagnostic Imaging; 4.1 Introduction; 4.2 Factors to Consider in Biomarker Selection for Imaging 4.3 Defining the Insertion Point of the Assay and Its Business Case4.4 Practical In Vitro Methods Used to Identify Biomarkers; 4.5 Preclinical Models; 4.6 Preclinical Analysis Techniques; 4.7 Translational Considerations and Restrictions; 4.8 Other Uses of Preclinical Models; 4.9 Nuclear Imaging Infrastructure; 4.10 Image Processing; 4.11 Concluding Remarks; References; Chapter 5: Breath: An Often Overlooked Medium in Biomarker Discovery; 5.1 Introduction; 5.2 Breath Analysis Studies: Targets, Techniques, and Approaches; 5.3 Biomarker Confounders; 5.4 Biomarkers in Breath 5.5 Outlook for Breath AnalysisAcknowledgments; References; Chapter 6: HTA in Personalized Medicine Technologies; 6.1 Introduction; 6.2 Health Technology Assessment (HTA); 6.3 Validation and Evaluation of Biomarker Tests; 6.4 Health Technology Assessment of Personalized Medicine Technologies; 6.5 Concluding Remarks; References; Chapter 7: Bone Remodeling Biomarkers: New Actors on the Old Cardiovascular Stage; 7.1 Introduction; 7.2 Cardiovascular Disease and Osteoporosis: Common Risk Factors and Common Pathophysiological Mechanisms; 7.3 Biomarkers of Bone Health in CVD; 7.4 Conclusion
9783527680658 3527680659 9783527680665 3527680667 3527337199 9783527337194 9783527680672 (Epub) 3527680675 (Epub) 9783527680689 (mobi) 3527680683 (mobi)
Biochemical markers.
Electronic books.
Electronic books.
Electronic books.
QH438.4.B55
572.86
Includes bibliographical references and index.
Related Titles; Title Page; Copyright; Table of Contents; List of Contributors; Chapter 1: Biomarkers -- Past and Future; 1.1 Introduction; 1.2 Definitions of Biomarkers; 1.3 Biomarkers in the Past; 1.4 Novel Molecules and Structural Classes of Biomarkers by New Technologies; 1.5 Biomarkers in Drug Research; 1.7 Summary and Outlook; References; Chapter 2: Quantitative Proteomics Techniques in Biomarker Discovery; 2.1 Introduction; 2.2 2D-Difference Gel Electrophoresis; 2.3 Mass Spectrometry-Based Proteomics; 2.4 MALDI Mass Spectrometry Imaging; 2.5 Conclusion; References Chapter 3: Biomarker Qualification: A Company Point of View3.1 Introduction; 3.2 Biomarker Uses; 3.3 Biomarker Types; 3.4 Validation vs. Qualification; 3.5 Strategic Choices in Business Models; 3.6 Validation of Analytical Methods; 3.7 Clinical Qualification of Candidate Biomarkers; 3.8 Biomarker Qualification in the'omics Era; 3.9 An Example of a Biomarker Provider; 3.10 Conclusion; References; Chapter 4: Biomarker Discovery and Medical Diagnostic Imaging; 4.1 Introduction; 4.2 Factors to Consider in Biomarker Selection for Imaging 4.3 Defining the Insertion Point of the Assay and Its Business Case4.4 Practical In Vitro Methods Used to Identify Biomarkers; 4.5 Preclinical Models; 4.6 Preclinical Analysis Techniques; 4.7 Translational Considerations and Restrictions; 4.8 Other Uses of Preclinical Models; 4.9 Nuclear Imaging Infrastructure; 4.10 Image Processing; 4.11 Concluding Remarks; References; Chapter 5: Breath: An Often Overlooked Medium in Biomarker Discovery; 5.1 Introduction; 5.2 Breath Analysis Studies: Targets, Techniques, and Approaches; 5.3 Biomarker Confounders; 5.4 Biomarkers in Breath 5.5 Outlook for Breath AnalysisAcknowledgments; References; Chapter 6: HTA in Personalized Medicine Technologies; 6.1 Introduction; 6.2 Health Technology Assessment (HTA); 6.3 Validation and Evaluation of Biomarker Tests; 6.4 Health Technology Assessment of Personalized Medicine Technologies; 6.5 Concluding Remarks; References; Chapter 7: Bone Remodeling Biomarkers: New Actors on the Old Cardiovascular Stage; 7.1 Introduction; 7.2 Cardiovascular Disease and Osteoporosis: Common Risk Factors and Common Pathophysiological Mechanisms; 7.3 Biomarkers of Bone Health in CVD; 7.4 Conclusion
9783527680658 3527680659 9783527680665 3527680667 3527337199 9783527337194 9783527680672 (Epub) 3527680675 (Epub) 9783527680689 (mobi) 3527680683 (mobi)
Biochemical markers.
Electronic books.
Electronic books.
Electronic books.
QH438.4.B55
572.86